柴胡와 酸漿 복합제가 LPS로 유도된 우울증에 미치는 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이원행 | - |
dc.contributor.author | 김도훈 | - |
dc.contributor.author | 이태희 | - |
dc.date.available | 2020-02-28T13:44:54Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11585 | - |
dc.description.abstract | Objectives : The effect of mixture extracted from Bupleuri Radix and Physalidis Herba(BR+RH) on the LPS-induced Depression in rats was investigated. Methods : Rats were administered intragastrically BR+PH after injectio of LPS to induce deprssion. Immobility was examined using Tail Suspension Test(TST), Forced Swimming Test(FST). The level of plasma corticosterone was measured by an Enzyme-Linked Immunosorbent Assay(ELISA) method. The expressions of c-Fos, Corticotropin Releasing Factor(CRF), NADPH-d in the Paraventricular nucleus(PVN) and TH in the Locus coeruleus(LC) were measured by immunohistochemical method. Results : In the effect of BR+PH on TST, immobility was significantly decreased comparing with the LPS group. In FST, immobility was shown decrease tendency in the BR+PH group. The expression of c-Fos in the PVN was significantly decreased at BR+PH400 group, comparing with the LPS group. The expression of CRF in PVN was shown dto have the decrease tendency in the BR+PH group, comparing with the LPS group. The expression of NADPH-d in PVN was not significantly decreased at BR+PH groups, comparing with the LPS group. The expression of TH in the LC was shown to have the decrease tendency at BR+RH groups, but not significantly, comparing with the LPS group. Conclusions : Anti-depressant effect of mixture after extracted from Bupleuri Radix and Physalidis Herba was through the anti-inflammatory effect via inhibition of HPA axis. NO and catecholamine system is not involved. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | 柴胡와 酸漿 복합제가 LPS로 유도된 우울증에 미치는 효과 | - |
dc.title.alternative | Effect of Mixture extracted from Bupleuri Radix and Physalidis Herba on the LPS-induced depression in Rats. | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.30, no.3, pp.69 - 76 | - |
dc.identifier.kciid | ART001995822 | - |
dc.citation.endPage | 76 | - |
dc.citation.startPage | 69 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 김도훈 | - |
dc.contributor.affiliatedAuthor | 이태희 | - |
dc.subject.keywordAuthor | Bupleuri Radix | - |
dc.subject.keywordAuthor | Physalidis Herba | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | anti-depressant | - |
dc.subject.keywordAuthor | HPA axis | - |
dc.description.journalRegisteredClass | kci | - |
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