Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation
DC Field | Value | Language |
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dc.contributor.author | Choi, Boyoon | - |
dc.contributor.author | Kim, Myeong Gyu | - |
dc.contributor.author | Han, Nayoung | - |
dc.contributor.author | Kim, Therasa | - |
dc.contributor.author | Ji, Eunhee | - |
dc.contributor.author | Park, Seonyang | - |
dc.contributor.author | Kim, In-Wha | - |
dc.contributor.author | Oh, Jung Mi | - |
dc.date.available | 2020-02-28T14:44:20Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1462-2416 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11841 | - |
dc.description.abstract | Aim: A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation. Patients & methods: A PPK model was developed from 36 patients by a one-compartment model with first-order elimination. Results: The typical value of clearance and volume of distribution were 11.0 l/h and 42.4 l, respectively. Clearance decreased by 15% and area under the concentration-time curves (AUCs) increased with GSTA1 variants compared with wild-type (both p < 0.05). Subtherapeutic AUCs were seen only in wild-type patients. Conclusion: To our knowledge, this is the first PPK study to suggest that GSTA1 polymorphisms in adults are associated with busulfan PK. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FUTURE MEDICINE LTD | - |
dc.relation.isPartOf | PHARMACOGENOMICS | - |
dc.subject | BONE-MARROW-TRANSPLANTATION | - |
dc.subject | S-TRANSFERASE A1 | - |
dc.subject | VERSUS-HOST-DISEASE | - |
dc.subject | HIGH-DOSE BUSULFAN | - |
dc.subject | INTRAVENOUS BUSULFAN | - |
dc.subject | VENOOCCLUSIVE DISEASE | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | PEDIATRIC-PATIENTS | - |
dc.subject | SYSTEMIC EXPOSURE | - |
dc.subject | ADULT PATIENTS | - |
dc.title | Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000363397900005 | - |
dc.identifier.doi | 10.2217/pgs.15.98 | - |
dc.identifier.bibliographicCitation | PHARMACOGENOMICS, v.16, no.14, pp.1585 - 1594 | - |
dc.identifier.scopusid | 2-s2.0-84945541160 | - |
dc.citation.endPage | 1594 | - |
dc.citation.startPage | 1585 | - |
dc.citation.title | PHARMACOGENOMICS | - |
dc.citation.volume | 16 | - |
dc.citation.number | 14 | - |
dc.contributor.affiliatedAuthor | Ji, Eunhee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | allogeneic hematopoietic stem cell transplantation | - |
dc.subject.keywordAuthor | alloHSCT | - |
dc.subject.keywordAuthor | busulfan | - |
dc.subject.keywordAuthor | clinical outcomes | - |
dc.subject.keywordAuthor | genetic polymorphisms | - |
dc.subject.keywordAuthor | glutathione s-transferase a1 | - |
dc.subject.keywordAuthor | GSTA1 | - |
dc.subject.keywordAuthor | population pharmacokinetics | - |
dc.subject.keywordPlus | BONE-MARROW-TRANSPLANTATION | - |
dc.subject.keywordPlus | S-TRANSFERASE A1 | - |
dc.subject.keywordPlus | VERSUS-HOST-DISEASE | - |
dc.subject.keywordPlus | HIGH-DOSE BUSULFAN | - |
dc.subject.keywordPlus | INTRAVENOUS BUSULFAN | - |
dc.subject.keywordPlus | VENOOCCLUSIVE DISEASE | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | PEDIATRIC-PATIENTS | - |
dc.subject.keywordPlus | SYSTEMIC EXPOSURE | - |
dc.subject.keywordPlus | ADULT PATIENTS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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