Active-targeted pH-responsive albumin-photosensitizer conjugate nanoparticles as theranostic agents
DC Field | Value | Language |
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dc.contributor.author | Battogtokh, Gantumur | - |
dc.contributor.author | Ko, Young Tag | - |
dc.date.available | 2020-02-28T14:44:45Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11858 | - |
dc.description.abstract | The objective of this study was to develop an active-targeted, pH-responsive albumin-photosensitizer conjugate as a theranostic agent. Herein, a porphyrin derivative photosensitizer, pheophorbide-a (PheoA), was conjugated to bovine serum albumin (BSA) via a cis-aconityl linkage, and the conjugate was then linked with polyethylene glycosylated folate to improve targeting ability. Further, BSA-c-PheoA and folate (FA)-BSA-c-PheoA at a ratio of 2:1 were self-assembled to form nanoparticles with a mean hydrodynamic diameter of 121.47 +/- 11.60 nm. The release study exhibited that the photosensitizer was released 4.5-fold faster at pH 5.0 than at pH 7.4 when incubated for 24 h. Cellular uptake results showed that the FA-BSA-c-PheoA nanoparticles were readily taken up by B16F10 and MCF7 cancer cells. In vitro phototoxicity results showed that FA-BSA-c-PheoA NPs have higher efficacy on cancer cells compared to simple BSA-c-PheoA NPs. In vivo bioimaging results exhibited that FA-BSA-c-PheoA NPs greatly accumulated into the tumor area as compared to free PheoA. These results show that our prepared FA-BSA-c-PheoA NPs have the potential to be applied as theranostic agents in photodynamic therapy and photodiagnosis of cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.subject | UP-CONVERSION NANOPARTICLES | - |
dc.subject | PHOTODYNAMIC THERAPY | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | GOLD NANOCLUSTERS | - |
dc.subject | CANCER | - |
dc.subject | PACLITAXEL | - |
dc.subject | MICELLES | - |
dc.subject | ACID | - |
dc.subject | THERAPEUTICS | - |
dc.subject | NANOPROBES | - |
dc.title | Active-targeted pH-responsive albumin-photosensitizer conjugate nanoparticles as theranostic agents | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000366163900014 | - |
dc.identifier.doi | 10.1039/c5tb01719j | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY B, v.3, no.48, pp.9349 - 9359 | - |
dc.identifier.scopusid | 2-s2.0-84948769608 | - |
dc.citation.endPage | 9359 | - |
dc.citation.startPage | 9349 | - |
dc.citation.title | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.volume | 3 | - |
dc.citation.number | 48 | - |
dc.contributor.affiliatedAuthor | Battogtokh, Gantumur | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | UP-CONVERSION NANOPARTICLES | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | GOLD NANOCLUSTERS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | NANOPROBES | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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