AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis
DC Field | Value | Language |
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dc.contributor.author | Hossen, Muhammad Jahangir | - |
dc.contributor.author | Kim, Seung Cheol | - |
dc.contributor.author | Son, Young-Jin | - |
dc.contributor.author | Baek, Kwang-Soo | - |
dc.contributor.author | Kim, Eunji | - |
dc.contributor.author | Yang, Woo Seok | - |
dc.contributor.author | Jeong, Deok | - |
dc.contributor.author | Park, Jae Gwang | - |
dc.contributor.author | Kim, Han Gyung | - |
dc.contributor.author | Chung, Woo-Jae | - |
dc.contributor.author | Yoon, Keejung | - |
dc.contributor.author | Ryou, Chongsuk | - |
dc.contributor.author | Lee, Sang Yeol | - |
dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Cho, Jae Youl | - |
dc.date.available | 2020-02-28T14:45:44Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11917 | - |
dc.description.abstract | In traditional Chinese medicine, Persicaria chinensis L. has been prescribed to cure numerous inflammatory disorders. We previously analyzed the bioactivity of the methanol extract of this plant (Pc-ME) against LPS-induced NO and PGE(2) in RAW264.7 macrophages and found that it preventedHCl/EtOH-induced gastric ulcers in mice. The purpose of the current study was to explore the molecular mechanism by which Pc-ME inhibits activator protein-(AP-) 1 activation pathway and mediates its hepatoprotective activity. To investigate the putative therapeutic properties of Pc-ME against AP-1-mediated inflammation and hepatotoxicity, lipopolysaccharide-(LPS-) stimulated RAW264.7 and U937 cells, a monocyte-like human cell line, and an LPS/D-galactosamine(D-GalN-) induced acute hepatitis mouse model were employed. The expression of LPS-induced proinflammatory cytokines including interleukin-(IL-) 1 beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) was significantly diminished by Pc-ME. Moreover, Pc-ME reduced AP-1 activation and mitogen-activated protein kinase (MAPK) phosphorylation in both LPS-stimulated RAW264.7 cells and differentiated U937 cells. Additionally, we highlighted the hepatoprotective and curative effects of Pc-ME pretreated orally in a mouse model of LPS/D-GalN-intoxicated acute liver injury by demonstrating the significant reduction in elevated serum AST and ALT levels and histological damage. Therefore, these results strongly suggest that Pc-ME could function as an antihepatitis remedy suppressing MAPK/AP-1-mediated inflammatory events. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.relation.isPartOf | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | ETHANOL EXTRACT | - |
dc.subject | IN-VITRO | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | FULMINANT-HEPATITIS | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | LIVER | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | ACTIVATION | - |
dc.subject | INHIBITION | - |
dc.title | AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000354764000001 | - |
dc.identifier.doi | 10.1155/2015/608126 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.identifier.scopusid | 2-s2.0-84926676057 | - |
dc.citation.title | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeol | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ETHANOL EXTRACT | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | FULMINANT-HEPATITIS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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