Ultraviolet light and laser irradiation enhances the antibacterial activity of glucosamine-functionalized gold nanoparticles
DC Field | Value | Language |
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dc.contributor.author | Govindaraju, Saravanan | - |
dc.contributor.author | Ramasamy, Mohankandhasamy | - |
dc.contributor.author | Baskaran, Rengarajan | - |
dc.contributor.author | Ahn, Sang Jung | - |
dc.contributor.author | Yun, Kyusik | - |
dc.date.available | 2020-02-28T15:42:11Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/11980 | - |
dc.description.abstract | Here we report a novel method for the synthesis of glucosamine-functionalized gold nanoparticles (GlcN-AuNPs) using biocompatible and biodegradable glucosamine for antibacterial activity. GlcN-AuNPs were prepared using different concentrations of glucosamine. The synthesized AuNPs were characterized for surface plasmon resonance, surface morphology, fluorescence spectroscopy, and antibacterial activity. The minimum inhibitory concentrations (MICs) of the AuNPs, GlcN-AuNPs, and GlcN-AuNPs when irradiated by ultraviolet light and laser were investigated and compared with the MIC of standard kanamycin using Escherichia coli by the microdilution method. Laser-irradiated GlcN-AuNPs exhibited significant bactericidal activity against E. coli. Flow cytometry and fluorescence microscopic analysis supported the cell death mechanism in the presence of GlcN-AuNP-treated bacteria. Further, morphological changes in E. coli after laser treatment were investigated using atomic force microscopy and transmission electron microscopy. The overall results of this study suggest that the prepared nanoparticles have potential as a potent antibacterial agent for the treatment of a wide range of disease-causing bacteria. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.title | Ultraviolet light and laser irradiation enhances the antibacterial activity of glucosamine-functionalized gold nanoparticles | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000365122300008 | - |
dc.identifier.doi | 10.2147/IJN.S88318 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.10, pp.67 - 78 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84947443820 | - |
dc.citation.endPage | 78 | - |
dc.citation.startPage | 67 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Govindaraju, Saravanan | - |
dc.contributor.affiliatedAuthor | Ramasamy, Mohankandhasamy | - |
dc.contributor.affiliatedAuthor | Baskaran, Rengarajan | - |
dc.contributor.affiliatedAuthor | Yun, Kyusik | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | gold nanoparticles | - |
dc.subject.keywordAuthor | glucosamine | - |
dc.subject.keywordAuthor | light irradiation | - |
dc.subject.keywordAuthor | antibacterial activity | - |
dc.subject.keywordAuthor | bacterial morphology | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | SILVER | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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