Hypoxylonol F Isolated from Annulohypoxylon annulatum Improves Insulin Secretion by Regulating Pancreatic beta-cell Metabolism
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Hwang, Buyng Su | - |
dc.contributor.author | Choi, Pilju | - |
dc.contributor.author | Kim, Taejung | - |
dc.contributor.author | Kim, Youngseok | - |
dc.contributor.author | Song, Bong Geun | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Ham, Jungyeob | - |
dc.date.available | 2020-02-27T02:41:13Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1205 | - |
dc.description.abstract | Insulin plays a key role in glucose homeostasis and is hence used to treat hyperglycemia, the main characteristic of diabetes mellitus. Annulohypoxylon annulatum is an inedible ball-shaped wood-rotting fungus, and hypoxylon F is one of the major compounds of A. annulatum. The aim of this study is to evaluate the effects of hypoxylonol F isolated from A. annulatum on insulin secretion in INS-1 pancreatic beta-cells and demonstrate the molecular mechanisms involved. Glucose-stimulated insulin secretion (GSIS) values were evaluated using a rat insulin ELISA kit. Moreover, the expression of proteins related to pancreatic beta-cell metabolism and insulin secretion was evaluated using Western blotting. Hypoxylonol F isolated from A. annulatum was found to significantly enhance glucose-stimulated insulin secretion without inducing cytotoxicity. Additionally, hypoxylonol F enhanced insulin receptor substrate-2 (IRS-2) levels and activated the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway. Interestingly, it also modulated the expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) and pancreatic and duodenal homeobox 1 (PDX-1). Our findings showed that A. annulatum and its bioactive compounds are capable of improving insulin secretion by pancreatic beta-cells. This suggests that A. annulatum can be used as a therapeutic agent to treat diabetes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | BIOMOLECULES | - |
dc.subject | GLUCOSE | - |
dc.subject | PIOGLITAZONE | - |
dc.subject | METFORMIN | - |
dc.subject | SAFETY | - |
dc.subject | RISK | - |
dc.subject | PDX1 | - |
dc.subject | MASS | - |
dc.title | Hypoxylonol F Isolated from Annulohypoxylon annulatum Improves Insulin Secretion by Regulating Pancreatic beta-cell Metabolism | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000484457600040 | - |
dc.identifier.doi | 10.3390/biom9080335 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES, v.9, no.8 | - |
dc.identifier.scopusid | 2-s2.0-85070633712 | - |
dc.citation.title | BIOMOLECULES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Yamabe, Noriko | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Annulohypoxylon annulatum | - |
dc.subject.keywordAuthor | insulin | - |
dc.subject.keywordAuthor | PI3K | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | PPAR gamma | - |
dc.subject.keywordAuthor | PDX-1 | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | PIOGLITAZONE | - |
dc.subject.keywordPlus | METFORMIN | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PDX1 | - |
dc.subject.keywordPlus | MASS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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