Concurrent chemoradiotherapy followed by L-asparaginase-containing chemotherapy, VIDL, for localized nasal extranodal NK/T cell lymphoma: CISL08-01 phase II study
DC Field | Value | Language |
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dc.contributor.author | Kim, Seok Jin | - |
dc.contributor.author | Yang, Deok-Hwan | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.contributor.author | Kwak, Jae-Yong | - |
dc.contributor.author | Eom, Hyeon-Seok | - |
dc.contributor.author | Hong, Dae Sik | - |
dc.contributor.author | Won, Jong Ho | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Yoon, Dok Hyun | - |
dc.contributor.author | Cho, Jaeho | - |
dc.contributor.author | Nam, Taek-Keun | - |
dc.contributor.author | Lee, Sang-wook | - |
dc.contributor.author | Ahn, Yong Chan | - |
dc.contributor.author | Suh, Cheolwon | - |
dc.contributor.author | Kim, Won Seog | - |
dc.date.available | 2020-02-28T15:44:58Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0939-5555 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12132 | - |
dc.description.abstract | We conducted a phase II trial of concurrent chemoradiotherapy (CCRT) followed by 2 cycles of l-asparaginase-containing chemotherapy for patients who were newly diagnosed with stages IE and IIE nasal extranodal NK/T cell lymphoma (ENKTL). CCRT consisted of 40-44 Gy of radiotherapy with weekly administration of 30 mg/m(2) of cisplatin for 4 weeks. Two cycles of VIDL (etoposide (100 mg/m(2)), ifosfamide (1,200 mg/m(2)), and dexamethasone (40 mg) from days 1 to 3, and l-asparaginase (4,000 IU/m(2)) every other day from days 8 to 20) were administered sequentially. CCRT yielded a 90 % overall response rate without significant side effects in 30 patients, including 20 patients with complete response (CR); however, two patients showed distant disease progression. After CCRT, VIDL chemotherapy showed an 87 % final CR rate (26/30). Although grade III or IV hematologic toxicity was frequent during VIDL chemotherapy, no treatment-related mortality was observed, and l-asparaginase-associated toxicity was manageable. With a median follow-up of 44 months, 11 patients showed local (n = 4) and distant (n = 7) relapse or progression. The estimated 5-year progression-free and overall survival rates were 73 and 60 %, respectively. In conclusion, CCRT followed by l-asparaginase-containing chemotherapy is a feasible treatment for newly diagnosed stages IE/IIE nasal ENKTL. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | ANNALS OF HEMATOLOGY | - |
dc.subject | MULTICENTER | - |
dc.subject | RADIATION | - |
dc.subject | SMILE | - |
dc.subject | MODEL | - |
dc.title | Concurrent chemoradiotherapy followed by L-asparaginase-containing chemotherapy, VIDL, for localized nasal extranodal NK/T cell lymphoma: CISL08-01 phase II study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000342491800011 | - |
dc.identifier.doi | 10.1007/s00277-014-2137-6 | - |
dc.identifier.bibliographicCitation | ANNALS OF HEMATOLOGY, v.93, no.11, pp.1895 - 1901 | - |
dc.identifier.scopusid | 2-s2.0-84921760445 | - |
dc.citation.endPage | 1901 | - |
dc.citation.startPage | 1895 | - |
dc.citation.title | ANNALS OF HEMATOLOGY | - |
dc.citation.volume | 93 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Extranodal NK/T cell lymphoma | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Radiotherapy | - |
dc.subject.keywordAuthor | L-Asparaginase | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | SMILE | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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