Self-assembled polymeric nanoparticle of PEGylated chitosan-ceramide conjugate for systemic delivery of paclitaxel
DC Field | Value | Language |
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dc.contributor.author | Battogtokh, Gantumur | - |
dc.contributor.author | Ko, Young Tag | - |
dc.date.available | 2020-02-28T15:45:00Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1061-186X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12135 | - |
dc.description.abstract | Chitosan has been widely explored as one of the most favorable biomaterials for various pharmaceutical applications due to its biodegradability and biocompatibility. Here, we report novel PEGylated-chitosan-ceramide (PEG-CS-CE) that forms stable polymeric nanoparticles capable of functioning as efficient carriers of hydrophobic drug molecules. The chitosan-ceramide conjugate (CS-CE) was linked with amine-polyethyleneglycol (NH2-PEG(2000)) by using dicyclohexylcarbodiimide/N-hydroxysuccinimide (DCC-NHS) to obtain PEG-CS-CE that could exhibit steric stabilization in biological environments. The structure of the conjugate was determined by proton (H-1) NMR and FT-IR spectrometry. Under suitable conditions, the PEG-CS-CE self-assembled to form colloidally stable nanoparticles with a mean diameter of similar to 200 nm. Further, hydrophobic anti-tumor agent paclitaxel (PTX) was incorporated into the polymeric nanoparticle with 90% loading efficiency and 11.3% loading capacity via an emulsion-solvent evaporation method. The PTX-loaded PEG-CS-CE nanoparticle showed sustained release and exhibited higher cellular uptake and a comparable cytotoxic efficacy to that of free PTX on B16F10 melanoma and MCF-7 human breast adenocarcinoma cell lines. The empty nanoparticle showed no toxicity, indicating that the co-polymer is safe to use in drug delivery. The polymeric nanoparticle PEG-CS-CE developed by us represent promising nanocarriers of hydrophobic drug molecules. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | JOURNAL OF DRUG TARGETING | - |
dc.subject | ACID-MODIFIED CHITOSAN | - |
dc.subject | TARGETED DELIVERY | - |
dc.subject | ORAL DELIVERY | - |
dc.subject | IN-VITRO | - |
dc.subject | DRUG | - |
dc.title | Self-assembled polymeric nanoparticle of PEGylated chitosan-ceramide conjugate for systemic delivery of paclitaxel | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000343863500005 | - |
dc.identifier.doi | 10.3109/1061186X.2014.930469 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DRUG TARGETING, v.22, no.9, pp.813 - 821 | - |
dc.identifier.scopusid | 2-s2.0-84911467363 | - |
dc.citation.endPage | 821 | - |
dc.citation.startPage | 813 | - |
dc.citation.title | JOURNAL OF DRUG TARGETING | - |
dc.citation.volume | 22 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Battogtokh, Gantumur | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Ceramide | - |
dc.subject.keywordAuthor | chitosan | - |
dc.subject.keywordAuthor | paclitaxel | - |
dc.subject.keywordAuthor | PEGylation | - |
dc.subject.keywordAuthor | polymeric nanoparticle | - |
dc.subject.keywordPlus | ACID-MODIFIED CHITOSAN | - |
dc.subject.keywordPlus | TARGETED DELIVERY | - |
dc.subject.keywordPlus | ORAL DELIVERY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DRUG | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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