Bioactive Lignan Constituents from the Twigs of Lindera glauca
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Ha, Sang Keun | - |
dc.contributor.author | Suh, Won Se | - |
dc.contributor.author | Kim, Ho Kyung | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T15:45:16Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12150 | - |
dc.description.abstract | A bioassay-guided fractionation and chemical investigation of the MeOH extract from the twigs of Lindera glauca (SIEB. et ZUCC.) BLUME resulted in the isolation and identification of six lignans (1-6) including three new lignan derivatives, named linderuca A (1), B (2), and C (3). The structures of the new compounds (1-3) were determined on the basis of spectroscopic analyses, including two dimensional NMR and circular dichroism (CD) spectroscopy studies. The cytotoxic activities of the isolates (1-6) were evaluated by determining their inhibitory effects on human tumor cell lines. Compounds 1-5 showed antiproliferative activities against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values of 7.79-29.42 mu M. Based on the understanding that inflammation is a crucial cause of tumor progression, we also investigated the anti-inflammatory activities of the isolates (1-6) in the lipopolysaccharide-stimulated murine microglia BV-2 cell line by measuring nitric oxide (NO) levels. The new lignans (1-3) significantly inhibited NO production with IC50 values of 12.10, 9.48, and 9.87 mu M, respectively, without cytotoxicity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.relation.isPartOf | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.subject | DERIVATIVES | - |
dc.subject | ASSAY | - |
dc.subject | BLUME | - |
dc.subject | BARK | - |
dc.subject | ACID | - |
dc.title | Bioactive Lignan Constituents from the Twigs of Lindera glauca | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000343964600011 | - |
dc.identifier.doi | 10.1248/cpb.c14-00381 | - |
dc.identifier.bibliographicCitation | CHEMICAL & PHARMACEUTICAL BULLETIN, v.62, no.11, pp.1136 - 1140 | - |
dc.identifier.scopusid | 2-s2.0-84909594860 | - |
dc.citation.endPage | 1140 | - |
dc.citation.startPage | 1136 | - |
dc.citation.title | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 62 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Moon, Eunjung | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Lindera glauca | - |
dc.subject.keywordAuthor | Lauraceae | - |
dc.subject.keywordAuthor | lignan | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | BLUME | - |
dc.subject.keywordPlus | BARK | - |
dc.subject.keywordPlus | ACID | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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