Molecular epidemiology of norovirus GII.4 variants in children under 5 years with sporadic acute gastroenteritis in South Korea during 2006-2013
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Han-Gil | - |
dc.contributor.author | Lee, Sung-Geun | - |
dc.contributor.author | Kim, Ju-Eun | - |
dc.contributor.author | Yu, Kyeong-Sin | - |
dc.contributor.author | Lee, Deog-Yong | - |
dc.contributor.author | Park, Po-Hyun | - |
dc.contributor.author | Yoon, Mi-hye | - |
dc.contributor.author | Jho, Eek-Hoon | - |
dc.contributor.author | Kim, Jaehong | - |
dc.contributor.author | Paik, Soon-Young | - |
dc.date.available | 2020-02-28T15:45:26Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1386-6532 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12156 | - |
dc.description.abstract | Background: The global emergence of norovirus (NoV) GII.4 variants has raised public concerns in the world including South Korea since 1996. Objective: We analyzed seasonality and genotypic pattern for sporadic cases by norovirus GII-4 variants. Study design: To determine the epidemic status of GII.4 variants in South Korea during 2006-2013, 7301 fecal specimens were collected from children who were younger than 5 years and had sporadic acute gastroenteritis (AGE). Results: During the study period, NoVs were the most prevalent viral agent, detected in 877 (12.0%) of the 7301 fecal specimens from children with sporadic AGE. NoV GII strains predominantly accounted for 97.6% of all sporadic NoV infections. NoV GII.4 was the most prevalent genotype and comprised 67.6% of the NoV GII strains. However, seasonal prevalence of GII. 4 strains varied depending on the spread of GII. 4 variants. GII.4-2006b variant most predominantly circulated from 2006-2007 to 2009-2010 and persisted during other seasons. GII.4-2009 variant was first detected in January 2010 and predominantin 2011-2012. However, it was rapidly displaced by GII.4-2012 variant, which emerged in May 2012 and substantially circulated in 2012-2013. Conclusions: The frequent emergence and rapid spread of GII. 4 variants significantly affect the magnitude of sporadic NoV infections in children. Hence, to minimize the disease burden of NoV infections, GII.4 strains should be considered as a primary target for vaccine development against NoVs. (C) 2014 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL VIROLOGY | - |
dc.subject | GENETIC-ANALYSIS | - |
dc.subject | EMERGENCE | - |
dc.subject | OUTBREAKS | - |
dc.subject | PERSISTENCE | - |
dc.subject | MECHANISMS | - |
dc.subject | SPREAD | - |
dc.title | Molecular epidemiology of norovirus GII.4 variants in children under 5 years with sporadic acute gastroenteritis in South Korea during 2006-2013 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000344750100006 | - |
dc.identifier.doi | 10.1016/j.jcv.2014.08.018 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL VIROLOGY, v.61, no.3, pp.340 - 344 | - |
dc.identifier.scopusid | 2-s2.0-84908509216 | - |
dc.citation.endPage | 344 | - |
dc.citation.startPage | 340 | - |
dc.citation.title | JOURNAL OF CLINICAL VIROLOGY | - |
dc.citation.volume | 61 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kim, Jaehong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Viral gastroenteritis | - |
dc.subject.keywordAuthor | Norovirus | - |
dc.subject.keywordAuthor | Genogroup | - |
dc.subject.keywordAuthor | GII.4 variant | - |
dc.subject.keywordPlus | GENETIC-ANALYSIS | - |
dc.subject.keywordPlus | EMERGENCE | - |
dc.subject.keywordPlus | OUTBREAKS | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SPREAD | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.