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Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia

Authors
Oh, Pyung ChunKoh, Kwang KonSakuma, IchiroLim, SooLee, YongheeLee, SeungikLee, KyounghoonHan, Seung HwanShin, Eak Kyun
Issue Date
20-Oct-2014
Publisher
ELSEVIER IRELAND LTD
Keywords
Omega-3 fatty acids; Atherosclerosis; Insulin resistance; Hypertriglyceridemia
Citation
INTERNATIONAL JOURNAL OF CARDIOLOGY, v.176, no.3, pp.696 - 702
Journal Title
INTERNATIONAL JOURNAL OF CARDIOLOGY
Volume
176
Number
3
Start Page
696
End Page
702
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12193
DOI
10.1016/j.ijcard.2014.07.075
ISSN
0167-5273
Abstract
Background: Experimental studies demonstrate that higher intake of omega-3 fatty acids (n - 3 FA) improves insulin sensitivity, however, we reported that n - 3 FA 2 g therapy, most commonly used dosage did not significantly improve insulin sensitivity despite reducing triglycerides by 21% in patients. Therefore, we investigated the effects of different dosages of n - 3 FA in patients with hypertriglyceridemia. Methods: This was a randomized, single-blind, placebo-controlled, parallel study. Age, sex, and body mass index were matched among groups. All patients were recommended to maintain a low fat diet. Forty-four patients (about 18 had metabolic syndrome/type 2 diabetes mellitus) in each group were given placebo, n - 3 FA 1 (01), 2 (02), or 4 g (04), respectively daily for 2 months. Results: n - 3 FA therapy dose-dependently and significantly decreased triglycerides and triglycerides/HDL cholesterol and improved flow-mediated dilation, compared with placebo (by ANOVA). However, each n - 3 FA therapy did not significantly decrease high-sensitivity C-reactive protein and fibrinogen, compared with placebo. 01 significantly increased insulin levels and decreased insulin sensitivity (determined by QUICKI) and O2 significantly decreased plasma adiponectin levels relative to baseline measurements. Of note, when compared with placebo, each n - 3 FA therapy did not significantly change insulin, glucose, adiponectin, glycated hemoglobin levels and insulin sensitivity (by ANOVA). We observed similar results in a subgroup of patients with the metabolic syndrome. Conclusions: n - 3 FA therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation. Nonetheless, n - 3 FA therapy did not significantly improve acute-phase reactants and insulin sensitivity in patients with hypertriglyceridemia, regardless of dosages. (C) 2014 Published by Elsevier Ireland Ltd.
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