There is no association between the serotonin receptor gene and bipolar I disorder in the Korean population
- Authors
- Kim, Yong-Ku; Hwang, Jung-A; Lee, Heon-Jeong; Lee, Bun-Hee; Na, Kyoung-Sae
- Issue Date
- Oct-2014
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Bipolar disorder; Polymorphism; Mood stabilizer; Serotonin 1A receptor; Treatment
- Citation
- NORDIC JOURNAL OF PSYCHIATRY, v.68, no.7, pp.488 - 493
- Journal Title
- NORDIC JOURNAL OF PSYCHIATRY
- Volume
- 68
- Number
- 7
- Start Page
- 488
- End Page
- 493
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12220
- DOI
- 10.3109/08039488.2013.877071
- ISSN
- 0803-9488
- Abstract
- Objective: Despite the close relationship between the functional polymorphism C(-1019) G (rs6295) of the serotonergic 1A receptor (5-HT1A) and mood, few studies have investigated the relationship between rs6295 and bipolar disorder. Aims: In this study, we aimed to investigate whether rs6295 is associated with clinical prognosis and treatment response in patients with bipolar I disorder acute manic episodes. Methods : One hundred twenty-eight patients with bipolar I disorder and one hundred sixty-eight healthy controls were recruited. Associations between patients with bipolar I disorder and healthy controls were compared. In addition, age at onset, number of admissions, and treatment response, including response rate, mean changes in manic symptoms, number of anti-manic agents and the total dosage of mood stabilizers for acute manic symptoms were compared between the rs6295 GG and CG + CC groups in patients with bipolar I disorder. We conducted a separate subgroup analysis according to gender. Results : There were no differences in frequency between patients and controls. In patients with bipolar disorder, clinical prognosis and treatment response were no different between GG and CG + CC groups. However, in a subgroup analysis according to gender, male, but not female, patients in the GG group had a longer duration of illness and a greater number of both previous episodes and psychiatric ward admissions than did the GC + CC group. Conclusions : Further studies should investigate the relationship between 5-HT1A polymorphisms and bipolar disorder in terms of mood episode and gender.
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