Fabrication and Characterization of Quantum Dots-Bound Hydrogels with Fluorescent and Temperature-Sensitive Functionalities
- Authors
- Yoo, Ji-Hye; Lee, Sang-Wha
- Issue Date
- Oct-2014
- Publisher
- AMER SCIENTIFIC PUBLISHERS
- Keywords
- Hydrogel; Quantum Dots; Silica Nanoparticles; Fluorescence; PL
- Citation
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.14, no.10, pp.7648 - 7653
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- Volume
- 14
- Number
- 10
- Start Page
- 7648
- End Page
- 7653
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12224
- DOI
- 10.1166/jnn.2014.9411
- ISSN
- 1533-4880
- Abstract
- In this work, dual-functional composite particles possessing fluorescence and temperature-sensitive functionalities were developed in the form of QD-bound hydrogels for biomedical applications. First, the surface of silica nanoparticles (SNPs) was functionalized with olefin silanes, followed by hydrogel encapsulation through a radical polymerization. The encapsulated hydrogels were poly(N-isopropylacrylamide-co-acrylic acid) P(NIPAM-co-AAc) copolymer, showing the sensitive volume changes corresponding to the alternating temperature changes between 25 degrees C and 45 degrees C. At an optimal pH5, the hydrogel-encapsulated SNPs (SiO2@hydrogel) were effectively anchored by amino quantum dots (amino-QDs) through electrostatic (attractive) interactions between carboxylate groups of hydrogels and amine groups of QDs. QD-bound hydrogels with co-monomer ratio of [NIPAM:AAc = 83: 17 wt%] exhibited the higher PL intensity than other samples with [NIPAM: AAc = 96: 4 wt% or 91: 9 wt%], indicating that higher fraction of carboxylate groups by AAc induced the effective bounding with QDs possessing positively charged amine groups.
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