Comparison of Clinical Manifestations, Outcomes and Cerebrospinal Fluid Findings Between Herpes Simplex Type 1 and Type 2 Central Nervous System Infections in Adults
DC Field | Value | Language |
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dc.contributor.author | Moon, Song Mi | - |
dc.contributor.author | Kim, Tark | - |
dc.contributor.author | Lee, Eun Mi | - |
dc.contributor.author | Kang, Joong Koo | - |
dc.contributor.author | Lee, Sang-Ahm | - |
dc.contributor.author | Choi, Sang-Ho | - |
dc.date.available | 2020-02-28T15:46:43Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12225 | - |
dc.description.abstract | In previous reports on the viral causes of central nervous system (CNS) infections, it has been generally recognized that HSV-1 is a major cause of encephalitis, while HSV-2 is the predominant cause of aseptic meningitis in adults. To examine this matter, the clinical characteristics in the two types of HSV CNS infections were investigated. In a retrospective cohort study which included all adult patients (>= 16 years) between January 1999 and December 2013 in a 2,700-bed tertiary care hospital, all the patients in whom PCR of the CSF for HSV was positive were identified. Ninety-five patients with positive CSF PCR results for HSV were included, 21 with HSV-1 and 74 with HSV-2. Many patients with HSV-1 had encephalitis (13/21, 61.9%), whereas most patients with HSV-2 had meningitis (62/74, 83.8%). However, HSV-1 and HSV-2 accounted for similar proportion of patients with HSV encephalitis (13/25, 52.0% vs. 12/25, 48.0%). Neurological sequelae were more frequent among patients with HSV-1 (9/21, 42.9% vs. 6/74, 8.1%; P = 0.001). The present study suggests that HSV-2 is not only a major cause of aseptic meningitis, but also it may cause serious manifestation as HSV-1 encephalitis in adults. (C) 2014 Wiley Periodicals, Inc. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | JOURNAL OF MEDICAL VIROLOGY | - |
dc.subject | POLYMERASE-CHAIN-REACTION | - |
dc.subject | RECURRENT LYMPHOCYTIC MENINGITIS | - |
dc.subject | VARICELLA-ZOSTER-VIRUS | - |
dc.subject | ASEPTIC-MENINGITIS | - |
dc.subject | ENCEPHALITIS | - |
dc.subject | DIAGNOSIS | - |
dc.subject | FEATURES | - |
dc.subject | DNA | - |
dc.subject | HERPESVIRUSES | - |
dc.subject | POPULATION | - |
dc.title | Comparison of Clinical Manifestations, Outcomes and Cerebrospinal Fluid Findings Between Herpes Simplex Type 1 and Type 2 Central Nervous System Infections in Adults | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000340540500018 | - |
dc.identifier.doi | 10.1002/jmv.23999 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICAL VIROLOGY, v.86, no.10, pp.1766 - 1771 | - |
dc.identifier.scopusid | 2-s2.0-85027933057 | - |
dc.citation.endPage | 1771 | - |
dc.citation.startPage | 1766 | - |
dc.citation.title | JOURNAL OF MEDICAL VIROLOGY | - |
dc.citation.volume | 86 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Moon, Song Mi | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | herpes simplex virus | - |
dc.subject.keywordAuthor | meningitis | - |
dc.subject.keywordAuthor | encephalitis | - |
dc.subject.keywordPlus | POLYMERASE-CHAIN-REACTION | - |
dc.subject.keywordPlus | RECURRENT LYMPHOCYTIC MENINGITIS | - |
dc.subject.keywordPlus | VARICELLA-ZOSTER-VIRUS | - |
dc.subject.keywordPlus | ASEPTIC-MENINGITIS | - |
dc.subject.keywordPlus | ENCEPHALITIS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | HERPESVIRUSES | - |
dc.subject.keywordPlus | POPULATION | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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