Bidirectional Association between First-Episode Panic Disorder and Major Depressive Disorder in a Nationwide General Population Survey in Korea
- Authors
- Woo, Jungmin; Hong, Jin Pyo; Cho, Seong-Jin; Lee, Jun-Young; Joen, Hong Jin; Kim, Byung-Soo; Chang, Sung Man
- Issue Date
- 8-Jul-2019
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Lifetime Prevalence; Hazard Ratios; Composite International Diagnostic Interview; Age of Onset; Panic Disorder; Major Depressive Disorder
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.34, no.26
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 34
- Number
- 26
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1222
- DOI
- 10.3346/jkms.2019.34.e181
- ISSN
- 1011-8934
- Abstract
- Background: Panic disorder (PD) and major depressive disorder (MDD) can occur concurrently, despite different clinical manifestations. Because MDD and PD patients tend to have more complicated conditions, understanding the co-occurrence and pattern of these conditions is important. Here, we investigated the influence of PD and MDD on each other, with respect to time interval. Methods: Data from three national representative surveys were pooled (total 18,807 respondents), and the age of onset (AOO) of PD and MDD was analyzed. We performed Kaplan-Meier analysis to estimate separate survival functions, using the AOO of MDD and PD as the outcome. To understand the temporal effect of other disorders, we used a Cox proportional hazard model to estimate the hazard ratios for the onset of MDD/PD with other comorbidities as time-dependent covariates. Results: PD elevated the risk of subsequent MDD by 15-fold, whereas MDD elevated the risk of subsequent PD by 3.8-fold. The effect of such an elevation risk was significant for up to 2 years. Conclusion: The results revealed a bidirectional relationship between MDD and PD. Each disease represents a risk of a subsequent occurrence of the other, which lasts for a considerable duration.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1222)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.