HD047703, a New Promising Anti-Diabetic Drug Candidate: In Vivo Preclinical Studies
DC Field | Value | Language |
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dc.contributor.author | Kim, SoRa | - |
dc.contributor.author | Kim, Dae Hoon | - |
dc.contributor.author | Kim, Young-Seok | - |
dc.contributor.author | Ha, Tae-Young | - |
dc.contributor.author | Yang, Jin | - |
dc.contributor.author | Park, Soo Hyun | - |
dc.contributor.author | Jeong, Kwang Won | - |
dc.contributor.author | Rhee, Jae-Keol | - |
dc.date.available | 2020-02-28T16:42:44Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-09-30 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12276 | - |
dc.description.abstract | G-protein coupled receptor 119 (GPR119) has emerged as a novel target for the treatment of type 2 diabetes mellitus. GPR119 is involved in glucose-stimulated insulin secretion (GSIS) from the pancreatic beta-cells and intestinal cells. In this study, we identified a novel small-molecule GPR119 agonist, HD047703, which raises intracellular cAMP concentrations in pancreatic beta-cells and can be expected to potentiate glucose-stimulated insulin secretion from human GPR119 receptor stably expressing cells (CHO cells). We evaluated the acute efficacy of HD047703 by the oral glucose tolerance test (OGTT) in normal C57BL/6J mice. Then, chronic administrations of HD047703 were performed to determine its efficacy in various diabetic rodent models. Single administration of HD047703 caused improved glycemic control during OGTT in a dose-dependent manner in normal mice, and the plasma GLP-1 level was also increased. With respect to chronic efficacy, we observed a decline in blood glucose levels in db/db, ob/ob and DIO mice. These results suggest that HD047703 may be a potentially promising anti-diabetic agent. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.subject | TYPE-2 DIABETES-MELLITUS | - |
dc.subject | INCRETIN-BASED THERAPIES | - |
dc.subject | GPR119 AGONISTS | - |
dc.subject | BODY-WEIGHT | - |
dc.subject | AGENTS | - |
dc.subject | NIDDM | - |
dc.subject | MOUSE | - |
dc.title | HD047703, a New Promising Anti-Diabetic Drug Candidate: In Vivo Preclinical Studies | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000342856200004 | - |
dc.identifier.doi | 10.4062/biomolther.2014.035 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.22, no.5, pp.400 - 405 | - |
dc.identifier.kciid | ART001915268 | - |
dc.identifier.scopusid | 2-s2.0-84908042479 | - |
dc.citation.endPage | 405 | - |
dc.citation.startPage | 400 | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 22 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Jeong, Kwang Won | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | GPR119 agonist | - |
dc.subject.keywordAuthor | Type 2 diabetes | - |
dc.subject.keywordAuthor | GLP-1 | - |
dc.subject.keywordPlus | TYPE-2 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | INCRETIN-BASED THERAPIES | - |
dc.subject.keywordPlus | GPR119 AGONISTS | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | NIDDM | - |
dc.subject.keywordPlus | MOUSE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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