Ahnak functions as a tumor suppressor via modulation of TGF beta/Smad signaling pathway
DC Field | Value | Language |
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dc.contributor.author | Lee, I. H. | - |
dc.contributor.author | Sohn, M. | - |
dc.contributor.author | Lim, H. J. | - |
dc.contributor.author | Yoon, S. | - |
dc.contributor.author | Oh, H. | - |
dc.contributor.author | Shin, S. | - |
dc.contributor.author | Shin, J. H. | - |
dc.contributor.author | Oh, S-H | - |
dc.contributor.author | Kim, J. | - |
dc.contributor.author | Lee, D. K. | - |
dc.contributor.author | Noh, D. Y. | - |
dc.contributor.author | Bae, D. S. | - |
dc.contributor.author | Seong, J. K. | - |
dc.contributor.author | Bae, Y. S. | - |
dc.date.available | 2020-02-28T16:43:10Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-09-18 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12297 | - |
dc.description.abstract | We provide detailed mechanisms of Ahnak-mediated potentiation of transforming growth factor beta (TGF beta) signaling, which leads to a negative regulation of cell growth. We show that Smad3 interacts with Ahnak through MH2 domain and that Ahnak stimulates Smad3 localization into nucleus leading to potentiating TGF beta-induced transcriptional activity of R-Smad. Moreover, overexpression of Ahnak resulted in growth retardation and cell cycle arrest through downregulation of c-Myc and cyclin D1/D2. We describe results from analyses of Ahnak(-/-) mouse model expressing middle T antigen in a mammary gland-specific manner (MMTVTg/+ Ahnak(-/-)), which showed significantly progressed hyperplasia of mammary glands compared with MMTVTg/+ Ahnak(+/+). Finally, we screened multiple human breast cancer tissues and showed that the expression of Ahnak in cancer tissues is lower than that in control tissues by 50%. Taken together, these data indicate that Ahnak mediates a negative regulation of cell growth and acts as novel tumor suppressor through potentiation of TGF beta signaling. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | ONCOGENE | - |
dc.subject | MAMMARY-GLAND DEVELOPMENT | - |
dc.subject | C-MYC | - |
dc.subject | BETA | - |
dc.subject | PROTEIN | - |
dc.subject | IDENTIFICATION | - |
dc.subject | TARGET | - |
dc.subject | GENE | - |
dc.subject | PHOSPHATASE | - |
dc.subject | COMPLEX | - |
dc.title | Ahnak functions as a tumor suppressor via modulation of TGF beta/Smad signaling pathway | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000342007200006 | - |
dc.identifier.doi | 10.1038/onc.2014.69 | - |
dc.identifier.bibliographicCitation | ONCOGENE, v.33, no.38, pp.4675 - 4684 | - |
dc.identifier.scopusid | 2-s2.0-84896421792 | - |
dc.citation.endPage | 4684 | - |
dc.citation.startPage | 4675 | - |
dc.citation.title | ONCOGENE | - |
dc.citation.volume | 33 | - |
dc.citation.number | 38 | - |
dc.contributor.affiliatedAuthor | Oh, S-H | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MAMMARY-GLAND DEVELOPMENT | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PHOSPHATASE | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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