Identification of Antitumor Lignans from the Seeds of Morning Glory (Pharbitis nil)
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Woo, Kyeong Wan | - |
dc.contributor.author | Moon, Eunjung | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Zin | - |
dc.contributor.author | Son, Mi Won | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T16:44:39Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-08-06 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12368 | - |
dc.description.abstract | In the search for antitumor compounds from Korean natural resources, activity-guided fractionation and purification processes were used on seeds of morning glory (Pharbitis nil). Air-dried P. nil seeds were extracted with ethanol and separated into n-hexane, chloroform, ethyl acetate, and n-butanol. Four new lignans, pharbilignans A-D (1-4) were isolated from the most active ethyl acetate fraction of the ethanol extract. Their structures were characterized on the basis of spectroscopic methods, including one- and two-dimensional nuclear magnetic resonance (NMR) techniques, high resolution mass spectrometry (HRMS), and circular dichroism (CD) spectroscopy. The cytotoxic activities of the isolates (1-4) were evaluated by determining their inhibitory effects on four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) using a sulforhodamine B (SRB) bioassay. Pharbilignan C (3) showed potent cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values of 1.42, 0.16, 0.20, and 0.14 mu M, respectively. On the basis of the expanded understanding that inflammation is a crucial cause in tumor progress, we also evaluated anti-inflammatory activity of the isolates (1-4). Pharbilignan C (3) strongly inhibited nitric oxide (NO) production in the lipopolysaccharide (LPS)-activated BV-2 microglia cell line with an IC50 value of 12.8 mu M. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.subject | PHENOLIC CONSTITUENTS | - |
dc.subject | RESIN GLYCOSIDES | - |
dc.subject | CAFFEIC ACID | - |
dc.subject | NEOLIGNANS | - |
dc.subject | CELLS | - |
dc.subject | SEMEN | - |
dc.title | Identification of Antitumor Lignans from the Seeds of Morning Glory (Pharbitis nil) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000340080100013 | - |
dc.identifier.doi | 10.1021/jf501470k | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.31, pp.7746 - 7752 | - |
dc.identifier.scopusid | 2-s2.0-84905734797 | - |
dc.citation.endPage | 7752 | - |
dc.citation.startPage | 7746 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 62 | - |
dc.citation.number | 31 | - |
dc.contributor.affiliatedAuthor | Moon, Eunjung | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Pharbitis nil | - |
dc.subject.keywordAuthor | Convolvulaceae | - |
dc.subject.keywordAuthor | lignans | - |
dc.subject.keywordAuthor | structural elucidation | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordPlus | PHENOLIC CONSTITUENTS | - |
dc.subject.keywordPlus | RESIN GLYCOSIDES | - |
dc.subject.keywordPlus | CAFFEIC ACID | - |
dc.subject.keywordPlus | NEOLIGNANS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SEMEN | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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