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A NEW CYCLIC TRITERPENE SAPONIN FROM PHYTEUMA JAPONICUM

Authors
Kim, Chung SubKwon, Oh WookKim, Sun YeouKim, Ki HyunLee, Kang Ro
Issue Date
1-Aug-2014
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Phyteuma japonicum; Triterpene Saponin; NGF
Citation
HETEROCYCLES, v.89, no.8, pp.1913 - 1922
Journal Title
HETEROCYCLES
Volume
89
Number
8
Start Page
1913
End Page
1922
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12390
DOI
10.3987/COM-14-13035
ISSN
0385-5414
Abstract
A new cyclic triterpene saponin, phyteujaposide (1) and eight known compounds (2-9) were isolated from the leaves of Phyteuma japonicum. The structure of the new compound (1) was elucidated by 1D and 2D data analysis, acid hydrolysis and GC-MS. Compounds 7 and 9 potently inhibited the NO production in LPS-activated BV-2 cells and compounds 5 and 6 showed a significant secretion induction of NGF in C6 glioma without cell toxicity.
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Pharmacy (Dept.of Pharmacy)
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