Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Jin-Sook | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Cho, Chul-Hyun | - |
dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Moon, Joung-Ho | - |
dc.contributor.author | Yang, Hee-Jung | - |
dc.contributor.author | Song, Hyun-Mi | - |
dc.contributor.author | Kim, Leen | - |
dc.date.available | 2020-02-28T16:45:38Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 0742-0528 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12421 | - |
dc.description.abstract | Previous studies have suggested that there is a genetic basis to restless legs syndrome (RLS) development. Occurrence of antipsychotic-induced RLS could also be due to differences in genetic susceptibility. We investigated whether CLOCK and NPAS2 gene polymorphisms are associated with RLS in schizophrenic patients on antipsychotics because RLS symptoms usually manifest during the evening and night. We assessed symptoms of RLS in 190 Korean schizophrenic patients on antipsychotics and divided the subjects into two groups according to the International Restless Legs Syndrome Study Group diagnostic criteria: (i) subjects who met all the criteria and (ii) the remaining subjects who did not meet all the criteria. We found a significant difference in the number of subjects with different genotype and allele carrier frequencies for the CLOCK gene (rs2412646) between the two groups (p = 0.031 and 0.010, respectively). Distribution of CLOCK haplotypes (rs2412646-rs1801260) was significantly different between schizophrenic patients with and without RLS (p = 0.021). However, the distributions of allelic, genotypic, and haplotypic variants of NPAS2 (rs2305160 and rs6725296) were not significantly different between the two groups. Our results suggest that CLOCK polymorphisms are associated with increased susceptibility of schizophrenic patients to RLS. We hypothesize that RLS in schizophrenia patients treated with antipsychotics may be a very mild akathisia that manifests during the night and is under control of circadian oscillation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.relation.isPartOf | CHRONOBIOLOGY INTERNATIONAL | - |
dc.subject | PERIODIC LIMB MOVEMENTS | - |
dc.subject | CIRCADIAN-RHYTHM | - |
dc.subject | MONOAMINE-OXIDASE | - |
dc.subject | SENSORY SYMPTOMS | - |
dc.subject | SUSCEPTIBILITY LOCUS | - |
dc.subject | DIURNAL-VARIATIONS | - |
dc.subject | KOREAN ADULTS | - |
dc.subject | RATING-SCALE | - |
dc.subject | SLEEP | - |
dc.subject | RECEPTORS | - |
dc.title | Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000338635000004 | - |
dc.identifier.doi | 10.3109/07420528.2014.914034 | - |
dc.identifier.bibliographicCitation | CHRONOBIOLOGY INTERNATIONAL, v.31, no.7, pp.838 - 844 | - |
dc.identifier.scopusid | 2-s2.0-84903723903 | - |
dc.citation.endPage | 844 | - |
dc.citation.startPage | 838 | - |
dc.citation.title | CHRONOBIOLOGY INTERNATIONAL | - |
dc.citation.volume | 31 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Kang, Seung-Gul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Antipsychotics | - |
dc.subject.keywordAuthor | circadian rhythm | - |
dc.subject.keywordAuthor | CLOCK gene | - |
dc.subject.keywordAuthor | restless legs syndrome | - |
dc.subject.keywordPlus | PERIODIC LIMB MOVEMENTS | - |
dc.subject.keywordPlus | CIRCADIAN-RHYTHM | - |
dc.subject.keywordPlus | MONOAMINE-OXIDASE | - |
dc.subject.keywordPlus | SENSORY SYMPTOMS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY LOCUS | - |
dc.subject.keywordPlus | DIURNAL-VARIATIONS | - |
dc.subject.keywordPlus | KOREAN ADULTS | - |
dc.subject.keywordPlus | RATING-SCALE | - |
dc.subject.keywordPlus | SLEEP | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.