Extract of Litsea japonica ameliorates blood-retinal barrier breakdown in db/db mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Junghyun | - |
dc.contributor.author | Kim, Chan-Sik | - |
dc.contributor.author | Lee, Ik Soo | - |
dc.contributor.author | Lee, Yun Mi | - |
dc.contributor.author | Sohn, Eunjin | - |
dc.contributor.author | Jo, Kyuhyung | - |
dc.contributor.author | Kim, Joo Hwan | - |
dc.contributor.author | Kim, Jin Sook | - |
dc.date.available | 2020-02-28T16:45:56Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1355-008X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12443 | - |
dc.description.abstract | Loss of blood-retinal barrier (BRB) properties is an important feature in the pathology of diabetic retinopathy. Endothelium integrity is important for the normal vascular function. Litsea japonica (Thunb.) Jussieu is a Korean native plant that is consumed as a vegetable food. In this study, we evaluated the ability of an ethanol extract of L. japonica to prevent retinal vascular leakages in db/db mice, which is an animal model of type II diabetes. L. japonica extracts (LJE, 100 and 250 mg/kg) were administered once a day, orally, for 12 weeks. Vehicle-treated db/db mice exhibited hyperglycemia and retinal vascular leakage. LJE treatment blocked diabetes-induced BRB breakdown and decreased retinal VEGF expression in db/db mice. LJE also inhibited the degradation of occludin, which is an important tight junction protein. These findings support the potential therapeutic usefulness of L. japonica for retinal vascular permeability diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | ENDOCRINE | - |
dc.title | Extract of Litsea japonica ameliorates blood-retinal barrier breakdown in db/db mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000339804200014 | - |
dc.identifier.doi | 10.1007/s12020-013-0085-x | - |
dc.identifier.bibliographicCitation | ENDOCRINE, v.46, no.3, pp.462 - 469 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84904562047 | - |
dc.citation.endPage | 469 | - |
dc.citation.startPage | 462 | - |
dc.citation.title | ENDOCRINE | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Blood-retinal barrier | - |
dc.subject.keywordAuthor | Diabetic retinopathy | - |
dc.subject.keywordAuthor | Litsea japonica | - |
dc.subject.keywordAuthor | Vascular endothelial growth factor | - |
dc.subject.keywordAuthor | Occludin | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | DIABETIC-RETINOPATHY | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | OCCLUDIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | LEAVES | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
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