Clinical significance of autophagic protein LC3 levels and its correlation with XIAP expression in hepatocellular carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wu, Wen-Yong | - |
dc.contributor.author | Kim, Hyunchul | - |
dc.contributor.author | Zhang, Chang-Le | - |
dc.contributor.author | Meng, Xiang-Ling | - |
dc.contributor.author | Wu, Zheng-Sheng | - |
dc.date.available | 2020-02-28T16:46:03Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1357-0560 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12447 | - |
dc.description.abstract | Autophagy is a cellular recycling process to enable cell survival in less favorable conditions through degradation of their unnecessary cellular components and utilization of the breakdown components. Autophagy also plays an important role in tumor pathology. In this study, we detected autophagy protein light chain 3 (LC3) and X-linked inhibitor of apoptosis protein (XIAP) in hepatocellular carcinoma (HCC) tissue specimens to assess their role in HCC tumorigenesis and progression. We analyzed expression of LC3, XIAP, and Ki-67 proteins immunohistochemically in surgical specimen of 150 HCC and 136 nontumor hepatic tissues. The levels of LC3 and XIAP proteins were compared between tumor and nontumoral parenchyme. The data showed that LC3 expression was increased in HCC compared with nontumoral parenchyma. LC3 expression was significantly associated with male gender, large tumor size, advanced tumor stages, and worse relapse-free and overall survival (OS). In contrast, XIAP expression was associated with small tumor size, early tumor stage, and better relapse-free and OS. In contrast, XIAP expression was associated with small tumor size, early tumor stage, and better relapse-free and OS. Furthermore, expression of LC3 and XIAP was inversely associated in HCC tissue specimens. In conclusion, increase in autophagic LC3 activity and low XIAP expression could be useful to predict the worse HCC prognosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HUMANA PRESS INC | - |
dc.relation.isPartOf | MEDICAL ONCOLOGY | - |
dc.subject | X-LINKED-INHIBITOR | - |
dc.subject | CANCER STEM-CELLS | - |
dc.subject | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject | APOPTOSIS PROTEINS | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | DEATH | - |
dc.subject | SURVIVAL | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | TUMORIGENESIS | - |
dc.subject | METASTASIS | - |
dc.title | Clinical significance of autophagic protein LC3 levels and its correlation with XIAP expression in hepatocellular carcinoma | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000340095700027 | - |
dc.identifier.doi | 10.1007/s12032-014-0108-3 | - |
dc.identifier.bibliographicCitation | MEDICAL ONCOLOGY, v.31, no.8 | - |
dc.identifier.scopusid | 2-s2.0-84903802616 | - |
dc.citation.title | MEDICAL ONCOLOGY | - |
dc.citation.volume | 31 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Kim, Hyunchul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | LC3 | - |
dc.subject.keywordAuthor | XIAP | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordPlus | X-LINKED-INHIBITOR | - |
dc.subject.keywordPlus | CANCER STEM-CELLS | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | APOPTOSIS PROTEINS | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | TUMORIGENESIS | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.