Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis
DC Field | Value | Language |
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dc.contributor.author | Byun, Kyunghee | - |
dc.contributor.author | Gil, So Young | - |
dc.contributor.author | Namkoong, Churl | - |
dc.contributor.author | Youn, Byung-Soo | - |
dc.contributor.author | Huang, Hu | - |
dc.contributor.author | Shin, Mi-Seon | - |
dc.contributor.author | Kang, Gil Myoung | - |
dc.contributor.author | Kim, Hyun-Kyong | - |
dc.contributor.author | Lee, Bonghee | - |
dc.contributor.author | Kim, Young-Bum | - |
dc.contributor.author | Kim, Min-Seon | - |
dc.date.available | 2020-02-28T16:46:58Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12488 | - |
dc.description.abstract | Hypothalamic leptin signaling plays a central role in maintaining body weight homeostasis. Here, we show that clusterin/ApoJ, recently identified as an anorexigenic neuropeptide, is an important regulator in the hypothalamic leptin signaling pathway. Coadministration of clusterin potentiates the anorexigenic effect of leptin and boosts leptin-induced hypothalamic Stat3 activation. In cultured neurons, clusterin enhances receptor binding and subsequent endocytosis of leptin. These effects are mainly mediated through the LDL receptor-related protein-2 (Lrp2). Notably, inhibition of hypothalamic clusterin, Lrp2 or endocytosis abrogates anorexia and hypothalamic Stat3 activation caused by leptin. These findings propose a novel regulatory mechanism in central leptin signaling pathways. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | EMBO REPORTS | - |
dc.subject | APOLIPOPROTEIN-J/CLUSTERIN | - |
dc.subject | HYPOTHALAMUS | - |
dc.subject | RECEPTOR | - |
dc.subject | IDENTIFICATION | - |
dc.subject | LOCALIZATION | - |
dc.subject | METABOLISM | - |
dc.subject | MEGALIN | - |
dc.subject | STAT3 | - |
dc.subject | MICE | - |
dc.title | Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000338919900014 | - |
dc.identifier.doi | 10.15252/embr.201338317 | - |
dc.identifier.bibliographicCitation | EMBO REPORTS, v.15, no.7, pp.801 - 808 | - |
dc.identifier.scopusid | 2-s2.0-84903705433 | - |
dc.citation.endPage | 808 | - |
dc.citation.startPage | 801 | - |
dc.citation.title | EMBO REPORTS | - |
dc.citation.volume | 15 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Byun, Kyunghee | - |
dc.contributor.affiliatedAuthor | Lee, Bonghee | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | clusterin | - |
dc.subject.keywordAuthor | endocytosis | - |
dc.subject.keywordAuthor | leptin | - |
dc.subject.keywordAuthor | Lrp2 | - |
dc.subject.keywordAuthor | Stat3 | - |
dc.subject.keywordPlus | APOLIPOPROTEIN-J/CLUSTERIN | - |
dc.subject.keywordPlus | HYPOTHALAMUS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | MEGALIN | - |
dc.subject.keywordPlus | STAT3 | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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