Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, M. L. | - |
dc.contributor.author | Begeti, F. | - |
dc.contributor.author | Oh, J. H. | - |
dc.contributor.author | Lee, S. Y. | - |
dc.contributor.author | O'Keeffe, G. C. | - |
dc.contributor.author | Clelland, C. D. | - |
dc.contributor.author | Tyers, P. | - |
dc.contributor.author | Cho, Z. H. | - |
dc.contributor.author | Kim, Y. B. | - |
dc.contributor.author | Barker, R. A. | - |
dc.date.available | 2020-02-28T17:41:54Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 0969-9961 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12549 | - |
dc.description.abstract | Huntington's disease (HD) is an inherited neurodegenerative disorder that is classically defined by a triad of movement and cognitive and psychiatric abnormalities with a well-established pathology that affects the dopaminergic systems of the brain. This has classically been described in terms of an early loss of dopamine 02 receptors (D2R), although interestingly the treatments most effectively used to treat patients with HD block these same receptors. We therefore sought to examine the dopaminergic system in HD not only in terms of striatal function but also at extrastriatal sites especially the hippocampus, given that transgenic (Tg) mice also exhibit deficits in hippocampal-dependent cognitive tests and a reduction in adult hippocampal neurogenesis. We showed that there was an early reduction of D2R in both the striatum and dentate gyrus (DG) of the hippocampus in the R6/1 transgenic HD mouse ahead of any overt motor signs and before striatal neuronal loss. Despite downregulation of D2Rs in these sites, further reduction of the dopaminergic input to these sites by either medial forebrain bundle lesions or receptor blockade using sulpiride was able to improve both deficits in motor performance and adult hippocampal neurogenesis. In contrast, a reduction in dopaminergic innervation of the neurogenic niches resulted in impaired neurogenesis in healthy WT mice. This study therefore provides evidence that D2R blockade improves hippocampal and striatal deficits in HD mice although the underlying mechanism for this is unclear, and suggests that agents working within this network may have greater effects than previously thought. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | NEUROBIOLOGY OF DISEASE | - |
dc.subject | ADULT HIPPOCAMPAL NEUROGENESIS | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | INCREASES NEUROGENESIS | - |
dc.subject | STRIATAL NEURONS | - |
dc.subject | RECEPTOR-BINDING | - |
dc.subject | MICE | - |
dc.subject | DYSFUNCTION | - |
dc.subject | GENE | - |
dc.subject | PET | - |
dc.subject | D2 | - |
dc.title | Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000335098600002 | - |
dc.identifier.doi | 10.1016/j.nbd.2014.02.004 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF DISEASE, v.66, pp.19 - 27 | - |
dc.identifier.scopusid | 2-s2.0-84896307597 | - |
dc.citation.endPage | 27 | - |
dc.citation.startPage | 19 | - |
dc.citation.title | NEUROBIOLOGY OF DISEASE | - |
dc.citation.volume | 66 | - |
dc.contributor.affiliatedAuthor | Oh, J. H. | - |
dc.contributor.affiliatedAuthor | Lee, S. Y. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Huntington&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Dopamine | - |
dc.subject.keywordAuthor | Adult hippocampal neurogenesis | - |
dc.subject.keywordPlus | ADULT HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | INCREASES NEUROGENESIS | - |
dc.subject.keywordPlus | STRIATAL NEURONS | - |
dc.subject.keywordPlus | RECEPTOR-BINDING | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PET | - |
dc.subject.keywordPlus | D2 | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.