Anti-obesity effects of KR-66195, a synthetic DPP-IV inhibitor, in diet-induced obese mice and obese-diabetic ob/ob mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Kim, Yeon Wook | - |
dc.contributor.author | Oh, Hyunhee | - |
dc.contributor.author | Choi, Cheol Soo | - |
dc.contributor.author | Ahn, Jin Hee | - |
dc.contributor.author | Lee, Byung-Wan | - |
dc.contributor.author | Kang, Eun Seok | - |
dc.contributor.author | Cha, Bong Soo | - |
dc.contributor.author | Lee, Hyun Chul | - |
dc.date.available | 2020-02-28T17:42:37Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12589 | - |
dc.description.abstract | Objective. We investigated whether KR-66195, a new synthetic dipeptidyl dipeptidase IV inhibitor, could prevent weight gain, as well as improving glycemic control in diet-induced obese (DIO) and ob/ob mice. Materials/Methods. Male C57BL/6 mice were randomly assigned to the following groups: chow diet, high-fat diet, and high-fat diet with KR-66195. After KR-66195 treatment for eight weeks, intraperitoneal glucose tolerance tests were performed. A pair-feeding study was performed to investigate the mechanisms of the anti-obesity effects of KR-66195 in DIO mice. Female ob/ob mice were treated with KR-66195 for three weeks and compared to the vehicle-treated group. Results. In DIO mice, KR-66195 treatment increased the plasma glucagon-like peptide (GLP)-1 levels and improved glucose tolerance. This treatment also reduced body weight gain (5.38 +/- 0.94 g vs. 12.08 +/- 0.55 g, P < 0.01) and food intake (2.41 +/- 0.09 g vs. 2.79 +/- 0.11 g, P < 0.05). In ob/ob mice, KR-66195 treatment for three weeks resulted in comparable effects in DIO mice. In the pair-feeding study, KR-66195-treated mice exhibited a 16% increase in energy expenditure (kcal/h/kg lean body mass) without significant differences in body weight or activities compared with pair-fed mice. These results suggest that KR-66195 prevented weight gain in DIO mice by decreasing food intake, as well as increasing energy expenditure. Conclusions. KR-66195 markedly increased plasma levels of GLP-1, resulting in the probable improvement in glucose tolerance and reduced body weight and food intake. Thus, KR-66195 might be further developed as a therapeutic drug to treat obesity, as well as diabetes. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.relation.isPartOf | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.subject | DIPEPTIDYL PEPTIDASE-IV | - |
dc.subject | BROWN ADIPOSE-TISSUE | - |
dc.subject | FOOD-INTAKE | - |
dc.subject | THERMOGENESIS | - |
dc.subject | SENSITIVITY | - |
dc.subject | EXPRESSION | - |
dc.subject | PANCREAS | - |
dc.subject | AGONISTS | - |
dc.subject | SYSTEM | - |
dc.subject | RATS | - |
dc.title | Anti-obesity effects of KR-66195, a synthetic DPP-IV inhibitor, in diet-induced obese mice and obese-diabetic ob/ob mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000336640100008 | - |
dc.identifier.doi | 10.1016/j.metabol.2014.02.011 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, v.63, no.6, pp.793 - 799 | - |
dc.identifier.scopusid | 2-s2.0-84901241178 | - |
dc.citation.endPage | 799 | - |
dc.citation.startPage | 793 | - |
dc.citation.title | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.citation.volume | 63 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Oh, Hyunhee | - |
dc.contributor.affiliatedAuthor | Choi, Cheol Soo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Glucagon-like peptide (GLP)-1 | - |
dc.subject.keywordAuthor | KR-66195 | - |
dc.subject.keywordAuthor | Dipeptidyl peptidase (DPP)-IV | - |
dc.subject.keywordPlus | DIPEPTIDYL PEPTIDASE-IV | - |
dc.subject.keywordPlus | BROWN ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | THERMOGENESIS | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PANCREAS | - |
dc.subject.keywordPlus | AGONISTS | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | RATS | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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