Clinical significance of Ki-67 and p53 expression in curatively resected non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Ahn, Hee Kyung | - |
dc.contributor.author | Jung, Minkyu | - |
dc.contributor.author | Ha, Seung-Yeon | - |
dc.contributor.author | Lee, Jae-Ik | - |
dc.contributor.author | Park, Inkeun | - |
dc.contributor.author | Kim, Young Saing | - |
dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Sym, Sun Jin | - |
dc.contributor.author | Park, Jinny | - |
dc.contributor.author | Shin, Dong Bok | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Cho, Eun Kyung | - |
dc.date.available | 2020-02-28T17:42:40Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12592 | - |
dc.description.abstract | The aim of this study is to explore the association of Ki-67 and p53 expression with prognosis in non-small cell lung cancer (NSCLC) patients who underwent curative resection. We retrospectively identified 116 consecutive patients with stages I-III NSCLC who underwent curative resection at a single center from January 2007 to December 2012. Ki-67 and p53 expression was assessed by immunohistochemistry. Data on clinicopathologic features and survival were collected retrospectively. Ki-67 expression in 109 samples and p53 expression in 115 patients were analyzed. According to the results, 108 patients (99 %) showed at least some expression of Ki-67. The median Ki-67 expression level was 30 %. Positive p53 expression was observed in 91 (79 %) patients. Higher Ki-67 expression (> 40 %) was significantly more frequent in male (26 vs. 4 % in female, p = 0.002), ever-smoker (31 vs. 10 % in never-smoker, p = 0.024), and non-adenocarcinoma (30 vs. 11 % of adenocarcinoma, p = 0.012) patients. In univariable analysis, median disease-free survival (DFS) was shorter with higher Ki-67 expression (16.1 vs. 61.9 months in those with lower Ki-67 expression, p = 0.005), and p53 expression did not show an association with DFS. Among 42 patients with stage I NSCLC who did not receive adjuvant chemotherapy, DFS was significantly worse in patients with higher Ki-67 expression (2-year DFS rate 57 vs. 88 %, p = 0.018). In a Cox regression model, higher Ki-67 expression (> 40 %) was a significant independent prognostic factor associated with poorer DFS (HR 2.9, 95 % CI 1.3-6.2) along with TNM stage and age. Higher Ki-67 expression (> 40 %) showed an independent association with shorter DFS in NSCLC patients who underwent curative resection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | POSITIVE BREAST-CANCER | - |
dc.subject | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject | F-18-FLUORODEOXYGLUCOSE UPTAKE | - |
dc.subject | OUTCOME PREDICTION | - |
dc.subject | ENDOCRINE THERAPY | - |
dc.subject | KI67 EXPRESSION | - |
dc.subject | POOR-PROGNOSIS | - |
dc.subject | LABELING INDEX | - |
dc.subject | METAANALYSIS | - |
dc.title | Clinical significance of Ki-67 and p53 expression in curatively resected non-small cell lung cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000337094900088 | - |
dc.identifier.doi | 10.1007/s13277-014-1760-0 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, v.35, no.6, pp.5735 - 5740 | - |
dc.identifier.scopusid | 2-s2.0-84904724884 | - |
dc.citation.endPage | 5740 | - |
dc.citation.startPage | 5735 | - |
dc.citation.title | TUMOR BIOLOGY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Ahn, Hee Kyung | - |
dc.contributor.affiliatedAuthor | Jung, Minkyu | - |
dc.contributor.affiliatedAuthor | Ha, Seung-Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Ik | - |
dc.contributor.affiliatedAuthor | Park, Inkeun | - |
dc.contributor.affiliatedAuthor | Kim, Young Saing | - |
dc.contributor.affiliatedAuthor | Hong, Junshik | - |
dc.contributor.affiliatedAuthor | Sym, Sun Jin | - |
dc.contributor.affiliatedAuthor | Park, Jinny | - |
dc.contributor.affiliatedAuthor | Shin, Dong Bok | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Eun Kyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Non-small cell lung carcinoma | - |
dc.subject.keywordAuthor | Ki-67 | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | Immunostaining | - |
dc.subject.keywordAuthor | Resection | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | POSITIVE BREAST-CANCER | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | F-18-FLUORODEOXYGLUCOSE UPTAKE | - |
dc.subject.keywordPlus | OUTCOME PREDICTION | - |
dc.subject.keywordPlus | ENDOCRINE THERAPY | - |
dc.subject.keywordPlus | KI67 EXPRESSION | - |
dc.subject.keywordPlus | POOR-PROGNOSIS | - |
dc.subject.keywordPlus | LABELING INDEX | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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