BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration
DC Field | Value | Language |
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dc.contributor.author | Saglam, Aybike | - |
dc.contributor.author | Kim, Sukbum | - |
dc.contributor.author | Ahn, Kwangwook | - |
dc.contributor.author | Oh, Insuk | - |
dc.contributor.author | Lee, Kwan-Hee | - |
dc.date.available | 2020-02-28T17:43:08Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-05-28 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12614 | - |
dc.description.abstract | In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-dependent signaling as well as PI3K/PTEN-Akt-mTOR signaling. Moreover, BMP2-induced neurotrophic effects occur by stabilization of neuronal microtubules. Thus, these findings suggest that BMP2 can be a potential therapeutic target for nerve injury treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.subject | SPINAL-CORD | - |
dc.subject | AXON REGENERATION | - |
dc.subject | PROTEIN | - |
dc.subject | CNS | - |
dc.subject | INHIBITION | - |
dc.subject | GROWTH | - |
dc.title | BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000335856300001 | - |
dc.identifier.doi | 10.1097/WNR.0000000000000130 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, v.25, no.8, pp.549 - 555 | - |
dc.identifier.scopusid | 2-s2.0-84900410552 | - |
dc.citation.endPage | 555 | - |
dc.citation.startPage | 549 | - |
dc.citation.title | NEUROREPORT | - |
dc.citation.volume | 25 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Kim, Sukbum | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | bone morphogenetic protein 2 | - |
dc.subject.keywordAuthor | microtubule | - |
dc.subject.keywordAuthor | neuroprotection | - |
dc.subject.keywordAuthor | PI3K | - |
dc.subject.keywordAuthor | PTEN | - |
dc.subject.keywordPlus | SPINAL-CORD | - |
dc.subject.keywordPlus | AXON REGENERATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CNS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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