microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression
DC Field | Value | Language |
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dc.contributor.author | Heo, Mi Jeong | - |
dc.contributor.author | Kim, Young Mi | - |
dc.contributor.author | Koo, Ja Hyun | - |
dc.contributor.author | Yang, Yoon Mee | - |
dc.contributor.author | An, Jihyun | - |
dc.contributor.author | Lee, Sook-Kyung | - |
dc.contributor.author | Lee, Seung Jin | - |
dc.contributor.author | Kim, Kang Mo | - |
dc.contributor.author | Park, Joong-Won | - |
dc.contributor.author | Kim, Sang Geon | - |
dc.date.available | 2020-02-28T17:43:33Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12640 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is classified as a poor prognostic tumor, and becomes frequently aggressive. MicroRNAs emerge as key contributors to tumor progression. This study investigated whether miR-148a dysregulation differentiates poor prognosis of HCC, exploring new targets of miR-148a. miR-148a dysregulation discriminated not only the overall survival and recurrence free survival rates of HCC, but the microvascular invasion. In the human HCC samples, ubiquitin specific protease 4 (USP4) and sphingosine 1-phosphate receptor 1 (S1P1) were up-regulated as the new targets of miR-148a. USP4 and S1P1 were up-regulated in mesenchymal-type liver-tumor cells with miR-148a dysregulation, facilitating migration and proliferation of tumor cells. The inverse relationship between miR-148a and the identified targets was verified in a tumor xenograft model. In the analysis of human samples, the expression of USP4, but not S1P1, correlated with the decrease of miR-148a. In a heterotropic patient-derived HCC xenograft model, USP4 was also overexpressed in G1 and G2 tumors when miR-148a was dysregulated, reflecting the closer link between miR-148a and USP4 for a shift in the expansion phase of tumorgraft. In conclusion, miR-148a dysregulation affects the poor prognosis of HCC. Of the identified targets of miR-148a, USP4 overexpression may contribute to HCC progression towards more aggressive feature. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.subject | SPHINGOSINE KINASE 1 | - |
dc.subject | LARGE GENE LISTS | - |
dc.subject | CELL-MIGRATION | - |
dc.subject | INTERACTION NETWORKS | - |
dc.subject | CANCER | - |
dc.subject | TUMOR | - |
dc.subject | METASTASIS | - |
dc.subject | RECEPTOR | - |
dc.subject | 1-PHOSPHATE | - |
dc.subject | EXPRESSION | - |
dc.title | microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000336966600037 | - |
dc.identifier.doi | 10.18632/oncotarget.1920 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, v.5, no.9, pp.2792 - 2806 | - |
dc.identifier.scopusid | 2-s2.0-84901236446 | - |
dc.citation.endPage | 2806 | - |
dc.citation.startPage | 2792 | - |
dc.citation.title | ONCOTARGET | - |
dc.citation.volume | 5 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Lee, Seung Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | USP4 | - |
dc.subject.keywordAuthor | S1P1 | - |
dc.subject.keywordAuthor | miR-148a | - |
dc.subject.keywordAuthor | migration | - |
dc.subject.keywordAuthor | growth | - |
dc.subject.keywordPlus | SPHINGOSINE KINASE 1 | - |
dc.subject.keywordPlus | LARGE GENE LISTS | - |
dc.subject.keywordPlus | CELL-MIGRATION | - |
dc.subject.keywordPlus | INTERACTION NETWORKS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | 1-PHOSPHATE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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