In vivo imaging of human adipose-derived stem cells in Alzheimer's disease animal model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ha, Sungji | - |
dc.contributor.author | Ahn, Sangzin | - |
dc.contributor.author | Kim, Saeromi | - |
dc.contributor.author | Joo, Yuyoung | - |
dc.contributor.author | Chong, Young Hae | - |
dc.contributor.author | Suh, Yoo-Hun | - |
dc.contributor.author | Chang, Keun-A | - |
dc.date.available | 2020-02-28T17:43:47Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 1083-3668 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12653 | - |
dc.description.abstract | Stem cell therapy is a promising tool for the treatment of diverse conditions, including neurodegenerative diseases such as Alzheimer's disease (AD). To understand transplanted stem cell biology, in vivo imaging is necessary. Nanomaterial has great potential for in vivo imaging and several noninvasive methods are used, such as magnetic resonance imaging, positron emission tomography, fluorescence imaging (FI) and near-infrared FI. However, each method has limitations for in vivo imaging. To overcome these limitations, multimodal nanoprobes have been developed. In the present study, we intravenously injected human adipose-derived stem cells (hASCs) that were labeled with a multimodal nanoparticle, LEO-LIVE (TM)-Magnoxide 675 or 797 (BITERIALS, Seoul, Korea), into Tg2576 mice, an AD mouse model. After sequential in vivo tracking using Maestro Imaging System, we found fluorescence signals up to 10 days after injection. We also found strong signals in the brains extracted from hASC-transplanted Tg2576 mice up to 12 days after injection. With these results, we suggest that in vivo imaging with this multimodal nanoparticle may provide a useful tool for stem cell tracking and understanding stem cell biology in other neurodegenerative diseases. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL OPTICS | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | NANOPARTICLES | - |
dc.subject | FLUORESCENCE | - |
dc.subject | DELIVERY | - |
dc.subject | TRACKING | - |
dc.title | In vivo imaging of human adipose-derived stem cells in Alzheimer's disease animal model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000338334600007 | - |
dc.identifier.doi | 10.1117/1.JBO.19.5.051206 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL OPTICS, v.19, no.5 | - |
dc.identifier.scopusid | 2-s2.0-84891501351 | - |
dc.citation.title | JOURNAL OF BIOMEDICAL OPTICS | - |
dc.citation.volume | 19 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Ha, Sungji | - |
dc.contributor.affiliatedAuthor | Joo, Yuyoung | - |
dc.contributor.affiliatedAuthor | Chang, Keun-A | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | In vivo imaging | - |
dc.subject.keywordAuthor | nanoparticle | - |
dc.subject.keywordAuthor | fluorescence imaging | - |
dc.subject.keywordAuthor | human adipose-derived stem cells | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | FLUORESCENCE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | TRACKING | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Optics | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Optics | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.