Unusual Expression of Thyroid Transcription Factor 1 and Napsin A in Metastatic Adenoid Cystic Carcinoma of Extrapulmonary Origin in the Lung
DC Field | Value | Language |
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dc.contributor.author | An, Jungsuk | - |
dc.contributor.author | Park, Sanghui | - |
dc.contributor.author | Sung, Sun Hee | - |
dc.contributor.author | Cho, Min-Sun | - |
dc.contributor.author | Kim, Seung Cheol | - |
dc.date.available | 2020-02-28T17:44:03Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 0002-9173 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12666 | - |
dc.description.abstract | Objectives: Our study examines thyroid transcription factor I (TTF-1) expression in 40 primary adenoid cystic carcinomas (ACCs) arising in various sites and compares TTF-1 expression between primary and metastatic ACCs in 12 cases with distant metastases. Methods: Forty patients with ACCs, including 12 pairs of primary and metastatic ACCs, were evaluated for the immunohistochemical expression of TTF-1 (clone SPT24). In addition, 10 metastatic ACCs to the lung were tested on napsin A and a different TTF-1 antibody (clone 8G7G3) for further evaluation. Results: No primary ACCs showed TTF-1 immunoreactivity (clone SPT24). TTF-1 was positive in five (41.7%) of 12 metastatic ACCs; all five cases were found only in the lung and comprised five (50.0%) of 10 cases. In all positive cases, staining was focal and detected only in the cribriform histologic subtype. Staining patterns using both antibodies (both SPT24 and 8G7G3) were very similar, and TTF-1 positive tumor cells were also positive for napsin A. Extrapulmonary ACCs were all negative for TTF-1 regardless of origination and metastasis. Conclusions: TTF-1-and napsin A-positive ACCs in the lung should not be considered primary ACCs because TTF-1 and napsin A can be expressed in metastatic ACCs of the lung. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC CLINICAL PATHOLOGY | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CLINICAL PATHOLOGY | - |
dc.subject | FACTOR-I EXPRESSION | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | ANTIBODIES | - |
dc.subject | DIAGNOSIS | - |
dc.subject | NEOPLASIA | - |
dc.subject | OVARIAN | - |
dc.subject | CANCER | - |
dc.subject | UPDATE | - |
dc.subject | MARKER | - |
dc.title | Unusual Expression of Thyroid Transcription Factor 1 and Napsin A in Metastatic Adenoid Cystic Carcinoma of Extrapulmonary Origin in the Lung | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000335200400015 | - |
dc.identifier.doi | 10.1309/AJCPB0YIY6LQLQTG | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CLINICAL PATHOLOGY, v.141, no.5, pp.712 - 717 | - |
dc.identifier.scopusid | 2-s2.0-84902595231 | - |
dc.citation.endPage | 717 | - |
dc.citation.startPage | 712 | - |
dc.citation.title | AMERICAN JOURNAL OF CLINICAL PATHOLOGY | - |
dc.citation.volume | 141 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | An, Jungsuk | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Adenoid cystic carcinoma | - |
dc.subject.keywordAuthor | Thyroid transcription factor 1 | - |
dc.subject.keywordAuthor | Napsin A | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
dc.subject.keywordPlus | FACTOR-I EXPRESSION | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | NEOPLASIA | - |
dc.subject.keywordPlus | OVARIAN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordPlus | MARKER | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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