Flavonoid Glycosides from Hosta longipes, Their Inhibition on NO Production, and Nerve Growth Factor Inductive Effects
DC Field | Value | Language |
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dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Kwon, Oh Wook | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-28T17:44:13Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 0103-5053 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12670 | - |
dc.description.abstract | An extended phytochemical investigation of the leaves of Hosta longipes identified the new flavonoid glycoside, kaempferol-3-O-beta-D-glucopyranosyl-(1 -> 2)-[ 6'''-O-acetyl-beta-Dglucopyranoside]- 7-O-beta-D-glucopyranoside and five known flavonoid derivatives. The structures of two compounds were revealed by extensive NMR methods (H-1 and C-13 NMR, H-1-H-1 COSY, HMQC and HMBC) and chemical hydrolysis. NMR data of one of them are published for the first time. Bioactivities of six compounds revealed that five strongly inhibited the production of nitric oxide (NO) with IC50 values of 11.56-15.97 mu m in lipopolysaccharide (LPS)-stimulated BV-2 cells without cell toxicity. Two compounds showed moderate induction of secretion of nerve growth factor (NGF) in C6 glioma cells (124.70 +/- 7.71% and 117.02 +/- 3.60%, respectively). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SOC BRASILEIRA QUIMICA | - |
dc.relation.isPartOf | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | LEAVES | - |
dc.subject | CELLS | - |
dc.title | Flavonoid Glycosides from Hosta longipes, Their Inhibition on NO Production, and Nerve Growth Factor Inductive Effects | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000335817400014 | - |
dc.identifier.doi | 10.5935/0103-5053.20140060 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v.25, no.5, pp.907 - 912 | - |
dc.identifier.scopusid | 2-s2.0-84902318165 | - |
dc.citation.endPage | 912 | - |
dc.citation.startPage | 907 | - |
dc.citation.title | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | - |
dc.citation.volume | 25 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Hosta longipes | - |
dc.subject.keywordAuthor | flavonoid glycoside | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | nerve growth factor | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | LEAVES | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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