Seoul criteria for PiB(-) subcortical vascular dementia based on clinical and MRI variables
DC Field | Value | Language |
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dc.contributor.author | Kim, Geon Ha | - |
dc.contributor.author | Lee, Jae Hong | - |
dc.contributor.author | Seo, Sang Won | - |
dc.contributor.author | Ye, Byoung Seok | - |
dc.contributor.author | Cho, Hanna | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Noh, Young | - |
dc.contributor.author | Yoon, Cindy W. | - |
dc.contributor.author | Chin, Ju Hee | - |
dc.contributor.author | Oh, Seung Jun | - |
dc.contributor.author | Kim, Jae Seung | - |
dc.contributor.author | Choe, Yearn Seong | - |
dc.contributor.author | Lee, Kyung Han | - |
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Jeong, Jee Hyang | - |
dc.contributor.author | Na, Duk L. | - |
dc.date.available | 2020-02-28T17:44:48Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-04-29 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12695 | - |
dc.description.abstract | Objective:The purpose of this study was to propose new criteria for differentiating Pittsburgh compound B (PiB)-negative from PiB-positive subcortical vascular dementia (SVaD) using clinical and MRI variables.Methods:We measured brain amyloid deposition using PiB-PET in 77 patients with SVaD. All patients met DSM-IV criteria for vascular dementia and had severe white matter hyperintensities on MRI, defined as a cap or band 10 mm as well as a deep white matter lesion 25 mm. Eleven models were considered to differentiate PiB(-) from PiB(+) SVaD using 4 variables, including age, number of lacunes, medial temporal atrophy (MTA), and APOE epsilon 4. The ideal cutoff values in each of the 11 models were selected using the highest Youden index.Results:A total of 49 of 77 patients (63.6%) tested negative for PiB retention, while 28 (36.4%) tested positive for PiB retention. The ideal model for differentiating PiB(-) from PiB(+) SVaD was as follows: age 75 years, 5 lacunes, and MTA 3, which together yielded an accuracy of 67.5%.Conclusion:When patients meet the DSM-IV criteria for vascular dementia and also have severe white matter hyperintensities, younger age, greater number of lacunes, and lesser MTA, these are predictive of a PiB(-) scan in patients with SVaD.Classification of evidence:This study provides Class II evidence that the combination of younger age, greater number of lacunes, and lesser MTA identifies patients with SVaD at lower risk of Alzheimer disease pathology. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | NEUROLOGY | - |
dc.subject | PITTSBURGH COMPOUND-B | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | COGNITIVE IMPAIRMENT | - |
dc.subject | DIAGNOSTIC-CRITERIA | - |
dc.subject | BRAIN | - |
dc.subject | IDENTIFICATION | - |
dc.subject | MICROBLEEDS | - |
dc.subject | VALIDATION | - |
dc.subject | TRIALS | - |
dc.title | Seoul criteria for PiB(-) subcortical vascular dementia based on clinical and MRI variables | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000336495300014 | - |
dc.identifier.doi | 10.1212/WNL.0000000000000360 | - |
dc.identifier.bibliographicCitation | NEUROLOGY, v.82, no.17, pp.1529 - 1535 | - |
dc.identifier.scopusid | 2-s2.0-84902161314 | - |
dc.citation.endPage | 1535 | - |
dc.citation.startPage | 1529 | - |
dc.citation.title | NEUROLOGY | - |
dc.citation.volume | 82 | - |
dc.citation.number | 17 | - |
dc.contributor.affiliatedAuthor | Noh, Young | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PITTSBURGH COMPOUND-B | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | DIAGNOSTIC-CRITERIA | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MICROBLEEDS | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | TRIALS | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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