Anticarcinogenic Effects of Products of Heat-Processed Ginsenoside Re, a Major Constituent of Ginseng Berry, on Human Gastric Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Jang, Hyuk-Jai | - |
dc.contributor.author | Han, Im-Ho | - |
dc.contributor.author | Kim, Young-Joo | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Oh, Miyoung | - |
dc.contributor.author | Choi, Kyung-Chul | - |
dc.contributor.author | Kim, Su-Nam | - |
dc.contributor.author | Ham, Jungyeob | - |
dc.contributor.author | Eom, Dae-Woon | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.available | 2020-02-28T17:44:52Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-04-02 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12698 | - |
dc.description.abstract | Ginsenoside Re is a triol type triterpene glycoside and is abundantly present in ginseng berry. In the present study, we verified that ginsenoside Re can be transformed into less-polar ginsenosides, namely, Rg2, Rg6, and F4, by heat-processing. The products of heat-processed ginsenoside Re inhibited phosphorylation of CDK2 at Thr160 by upregulation of p21 level, resulting in S phase arrest. The products of heat-processed ginsenoside Re also activated caspase-8, caspase-9, and caspase-3, followed by cleavage of PARP, a substrate of caspase-3, in a dose-dependent manner. Concurrently, alteration of mitochondrial factors such as Bcl-2 and Bax was also observed. Moreover, pretreatment with Z-VAD-fmk abrogated caspase-8, -9, and -3 activations by the products of heat-processed ginsenoside Re. We further confirmed that the anticancer effects of the products of heat-processed ginsenoside Re in AGS cells are mainly mediated via generation of less-polar ginsenosides Rg6 and F4. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.subject | ADENOCARCINOMA CELLS | - |
dc.subject | GREEN TEA | - |
dc.subject | APOPTOSIS | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | RESVERATROL | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | PREVENTION | - |
dc.subject | INDUCTION | - |
dc.subject | INCREASE | - |
dc.subject | MIXTURE | - |
dc.title | Anticarcinogenic Effects of Products of Heat-Processed Ginsenoside Re, a Major Constituent of Ginseng Berry, on Human Gastric Cancer Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000333947800017 | - |
dc.identifier.doi | 10.1021/jf5000776 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.13, pp.2830 - 2836 | - |
dc.identifier.scopusid | 2-s2.0-84897500610 | - |
dc.citation.endPage | 2836 | - |
dc.citation.startPage | 2830 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 62 | - |
dc.citation.number | 13 | - |
dc.contributor.affiliatedAuthor | Yamabe, Noriko | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | ginsenoside Re | - |
dc.subject.keywordAuthor | heat-processing | - |
dc.subject.keywordAuthor | gastric cancer | - |
dc.subject.keywordAuthor | cell cycle arrest | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordPlus | ADENOCARCINOMA CELLS | - |
dc.subject.keywordPlus | GREEN TEA | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | INCREASE | - |
dc.subject.keywordPlus | MIXTURE | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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