Photoluminescent carbon nanotags from harmful cyanobacteria for drug delivery and imaging in cancer cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun Uk | - |
dc.contributor.author | Park, So Young | - |
dc.contributor.author | Park, Eun Sik | - |
dc.contributor.author | Son, Byoungchul | - |
dc.contributor.author | Lee, Soon Chang | - |
dc.contributor.author | Lee, Jae Won | - |
dc.contributor.author | Lee, Young-Chul | - |
dc.contributor.author | Kang, Kyoung Suk | - |
dc.contributor.author | Kim, Moon Il | - |
dc.contributor.author | Park, Hyun Gyu | - |
dc.contributor.author | Choi, Saehae | - |
dc.contributor.author | Huh, Yun Suk | - |
dc.contributor.author | Lee, Seung-Yeul | - |
dc.contributor.author | Lee, Kyung-Bok | - |
dc.contributor.author | Oh, You-Kwan | - |
dc.contributor.author | Lee, Jouhahn | - |
dc.date.available | 2020-02-28T17:44:53Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-04-11 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12699 | - |
dc.description.abstract | Using a simple method of mass production of green carbon nanotags (G-tags) from harmful cyanobacteria, we developed an advanced and efficient imaging platform for the purpose of anticancer therapy. Approximately 100 grams of G-tags per 100 kilograms of harmful cyanobacteria were prepared using our eco-friendly approach. The G-tags possess high solubility, excellent photostability, and low cytotoxicity (<1.5 mg/mL for 24 h). Moreover, doxorubicin-conjugated G-tags (T-tags; >0.1 mg/mL) induced death in cancer cells (HepG2 and MCF-7) in-vitro at a higher rate than that of only G-tags while in-vivo mice experiment showed enhanced anticancer efficacy by T-tags at 0.01 mg/mL, indicating that the loaded doxorubicin retains its pharmaceutical activity. The cancer cell uptake and intracellular location of the G- and T-tags were observed. The results indicate that these multifunctional T-tags can deliver doxorubicin to the targeted cancer cells and sense the delivery of doxorubicin by activating the fluorescence of G-tags. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.subject | MULTIFUNCTIONAL UNIMOLECULAR MICELLES | - |
dc.subject | ONE-STEP SYNTHESIS | - |
dc.subject | GOLD NANOPARTICLES | - |
dc.subject | QUANTUM-DOT | - |
dc.subject | NANODOTS | - |
dc.subject | NANOTUBES | - |
dc.subject | GRAPHENE | - |
dc.subject | THERAPY | - |
dc.title | Photoluminescent carbon nanotags from harmful cyanobacteria for drug delivery and imaging in cancer cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000334102200018 | - |
dc.identifier.doi | 10.1038/srep04665 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.4 | - |
dc.identifier.scopusid | 2-s2.0-84898652030 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 4 | - |
dc.contributor.affiliatedAuthor | Lee, Young-Chul | - |
dc.contributor.affiliatedAuthor | Kim, Moon Il | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MULTIFUNCTIONAL UNIMOLECULAR MICELLES | - |
dc.subject.keywordPlus | ONE-STEP SYNTHESIS | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | QUANTUM-DOT | - |
dc.subject.keywordPlus | NANODOTS | - |
dc.subject.keywordPlus | NANOTUBES | - |
dc.subject.keywordPlus | GRAPHENE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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