Detailed Information

Cited 12 time in webofscience Cited 15 time in scopus
Metadata Downloads

Pharmacokinetics and Metabolism of 4-O-Methylhonokiol in Rats

Authors
Yu, Hyung EunOh, Soo JinRyu, Je KyungKang, Jong SoonHong, Jin TaeJung, Jae-KyungHan, Sang-BaeSeo, Seung-YongKim, Young HeuiPark, Song-KyuKim, Hwan MookLee, Kiho
Issue Date
Apr-2014
Publisher
WILEY
Keywords
pharmacokinetics; 4-O-methylhonokiol; metabolism; honokiol; neolignan
Citation
PHYTOTHERAPY RESEARCH, v.28, no.4, pp.568 - 578
Journal Title
PHYTOTHERAPY RESEARCH
Volume
28
Number
4
Start Page
568
End Page
578
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12714
DOI
10.1002/ptr.5033
ISSN
0951-418X
Abstract
The purpose of this study was to characterize the pharmacokinetics and metabolism of 4-O-methylhonokiol in rats. The absorption and disposition of 4-O-methylhonokiol were investigated in male Sprague-Dawley rats following a single intravenous (2 mg/kg) or oral (10 mg/kg) dose. Its metabolism was studied in vitro using rat liver microsomes and cytosol. 4-O-Methylhonokiol exhibited a high systemic plasma clearance and a large volume of distribution. The oral dose gave a peak plasma concentration of 24.1 +/- 3.3 ng/mL at 2.9 +/- 1.9 h and a low estimated bioavailability. 4-O-Methylhonokiol was rapidly metabolized and converted at least in part to honokiol in a concentration-dependent manner by cytochrome P450 in rat liver microsomes, predicting a high systemic clearance consistent with the pharmacokinetic results. It was also shown to be metabolized by glucuronidation and sulfation in rat liver microsomes and cytosol, respectively. 4-O-Methylhonokiol showed a moderate permeability with no apparent vectorial transport across Caco-2 cells, suggesting that intestinal permeation process is not likely to limit its oral absorption. Taken together, these results suggest that the rapid hepatic metabolism of 4-O-methylhonokiol could be the major reason for its high systemic clearance and low oral bioavailability. Copyright (c) 2013 John Wiley & Sons, Ltd.
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Hwan Mook photo

Kim, Hwan Mook
Pharmacy (Dept.of Pharmacy)
Read more

Altmetrics

Total Views & Downloads

BROWSE