Comparison of platelet parameters in thrombocytopenic patients associated with acute myeloid leukemia and primary immune thrombocytopenia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Moon Jin | - |
dc.contributor.author | Park, Pil-Whan | - |
dc.contributor.author | Seo, Yiel-Hea | - |
dc.contributor.author | Kim, Kyung-Hee | - |
dc.contributor.author | Seo, Ja Young | - |
dc.contributor.author | Jeong, Ji-Hun | - |
dc.contributor.author | Park, Mi-Jung | - |
dc.contributor.author | Ahn, Jeong-Yeal | - |
dc.date.available | 2020-02-28T17:45:47Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 0957-5235 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12743 | - |
dc.description.abstract | Thrombocytopenia is caused by insufficient production and excessive destruction of platelets. Recent improvement of automated blood cell analyzers has allowed measurement of several platelet parameters, providing better understanding of the underlying mechanisms of thrombocytopenia. We investigated the significance of platelet parameters in thrombocytopenic patients. Thrombocytopenic patients (platelet <100 x 10(3)/mu l) who were newly diagnosed with acute myeloid leukemia and primary immune thrombocytopenia were enrolled, and platelet, mean platelet volume, platelet distribution width, platelet crit, mean platelet component, mean platelet mass, and large platelet count were measured, and the percentages of large platelets were calculated. The parameters were also measured in the reference population. The mean values of each parameter were as follows: platelet, 259 x 10(3)/mu l; mean platelet volume, 7.9 fl; platelet distribution width, 51.3%; platelet crit, 0.20%; mean platelet component, 26.0 g/dl; mean platelet mass, 1.9 pg; large platelet, 4.7 x 10(3)/mu l; large platelet percentage, 1.7%. In comparison with acute myeloid leukemia patients, patients with primary immune thrombocytopenia showed significantly higher mean platelet volume, platelet distribution width, mean platelet component, mean platelet mass, large platelet, and large platelet % (P < 0.05). Because of increased destruction of platelets, primary immune thrombocytopenia patients have increased mean platelet volume, platelet distribution width, mean platelet component, mean platelet mass, large platelet, and large platelet percentage compared with acute myeloid leukemia patients who have ineffective platelet production. Parameters measured by automated analyzer provide better understanding of thrombopoiesis in the bone marrow and the status of the peripheral blood in the clinical field. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | BLOOD COAGULATION & FIBRINOLYSIS | - |
dc.subject | BAYER ADVIA(TM) 120 | - |
dc.subject | LARGE-CELL RATIO | - |
dc.subject | SIZE | - |
dc.subject | DIAGNOSIS | - |
dc.subject | VOLUME | - |
dc.subject | PURPURA | - |
dc.subject | SENSITIVITY | - |
dc.subject | DISORDERS | - |
dc.subject | COUNT | - |
dc.title | Comparison of platelet parameters in thrombocytopenic patients associated with acute myeloid leukemia and primary immune thrombocytopenia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000333648900004 | - |
dc.identifier.doi | 10.1097/MBC.0000000000000027 | - |
dc.identifier.bibliographicCitation | BLOOD COAGULATION & FIBRINOLYSIS, v.25, no.3, pp.221 - 225 | - |
dc.identifier.scopusid | 2-s2.0-84897533752 | - |
dc.citation.endPage | 225 | - |
dc.citation.startPage | 221 | - |
dc.citation.title | BLOOD COAGULATION & FIBRINOLYSIS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kim, Moon Jin | - |
dc.contributor.affiliatedAuthor | Park, Pil-Whan | - |
dc.contributor.affiliatedAuthor | Seo, Yiel-Hea | - |
dc.contributor.affiliatedAuthor | Kim, Kyung-Hee | - |
dc.contributor.affiliatedAuthor | Seo, Ja Young | - |
dc.contributor.affiliatedAuthor | Jeong, Ji-Hun | - |
dc.contributor.affiliatedAuthor | Park, Mi-Jung | - |
dc.contributor.affiliatedAuthor | Ahn, Jeong-Yeal | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | thrombocytopenia | - |
dc.subject.keywordAuthor | blood platelets | - |
dc.subject.keywordAuthor | acute myeloid leukemia | - |
dc.subject.keywordAuthor | blood cell count | - |
dc.subject.keywordAuthor | idiopathic thrombocytopenic purpura | - |
dc.subject.keywordPlus | BAYER ADVIA(TM) 120 | - |
dc.subject.keywordPlus | LARGE-CELL RATIO | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | PURPURA | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | DISORDERS | - |
dc.subject.keywordPlus | COUNT | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.