Coordination-Driven Self-Assembly and Anticancer Potency Studies of Arene-Ruthenium-Based Molecular Metalla-Rectangles
DC Field | Value | Language |
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dc.contributor.author | Mishra, Anurag | - |
dc.contributor.author | Jeong, Yong Joon | - |
dc.contributor.author | Jo, Jae-Ho | - |
dc.contributor.author | Kang, Se Chan | - |
dc.contributor.author | Kim, Hyunuk | - |
dc.contributor.author | Chi, Ki-Whan | - |
dc.date.available | 2020-02-28T17:46:43Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-03-10 | - |
dc.identifier.issn | 0276-7333 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12787 | - |
dc.description.abstract | The two new large molecular metalla-rectangles 6 and 8 were obtained by the reaction of the two different arene-ruthenium acceptors [Ru-2(p-cymene)(2)(mu-eta(4)-C2O4)Cl-2] (2) and [Ru-2(p-cymene)(2)(donq)(Cl)(2)] (donq = 5,8-dioxido-1,4-naphthoquinonato) (4) with a symmetrical N,N'-bis(4-(pyridin-4-ylethynyl)phenyl)-terephthalamide (1) donor ligand. Both metalla-rectangles were isolated in good yields as triflate salts and were characterized by multinuclear NMR, ESI-MS, and UV-vis spectroscopy. X-ray crystallography of 6 confirmed a molecular metalla-rectangle. The cytotoxicities of metalla-rectangles 6-9 were established in SK-hep-1 (liver cancer), AGS (gastric cancer), and HCT-15 (colorectal cancer) human cancer cell lines. The cytotoxicity of metalla-rectangle 8 was found to be considerably stronger against all cancer cell lines, even much more effective than the well-known anticancer drugs doxorubicin and cisplatin. In addition, expressions of APC and p53, colorectal cancer suppressor genes, were significantly increased following exposure to the metalla-rectangle 8. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ORGANOMETALLICS | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | COMPLEXES | - |
dc.subject | DENDRIMERS | - |
dc.subject | CHEMISTRY | - |
dc.subject | ANTIBACTERIAL | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | CISPLATIN | - |
dc.subject | CRYSTAL | - |
dc.subject | RELEASE | - |
dc.subject | BINDING | - |
dc.title | Coordination-Driven Self-Assembly and Anticancer Potency Studies of Arene-Ruthenium-Based Molecular Metalla-Rectangles | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000332756800009 | - |
dc.identifier.doi | 10.1021/om401042m | - |
dc.identifier.bibliographicCitation | ORGANOMETALLICS, v.33, no.5, pp.1144 - 1151 | - |
dc.identifier.scopusid | 2-s2.0-84896777352 | - |
dc.citation.endPage | 1151 | - |
dc.citation.startPage | 1144 | - |
dc.citation.title | ORGANOMETALLICS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Jeong, Yong Joon | - |
dc.contributor.affiliatedAuthor | Kang, Se Chan | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | DENDRIMERS | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | ANTIBACTERIAL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | CRYSTAL | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | BINDING | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Inorganic & Nuclear | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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