The inhibitory effect of vitexin on the agonist-induced regulation of vascular contractility
DC Field | Value | Language |
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dc.contributor.author | Je, Hyun Gon | - |
dc.contributor.author | Hong, Seok Myeong | - |
dc.contributor.author | Je, Hyun Dong | - |
dc.contributor.author | Sohn, Uy Dong | - |
dc.contributor.author | Choi, Yun-Sik | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.contributor.author | Min, Young Sil | - |
dc.contributor.author | Chung, Su Jin | - |
dc.contributor.author | Shin, Yong Kyoo | - |
dc.contributor.author | Lee, Tae Jin | - |
dc.contributor.author | Park, Eon Sub | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.date.available | 2020-02-28T17:47:22Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0031-7144 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12821 | - |
dc.description.abstract | The present study was undertaken to investigate the influence of vitexin on vascular smooth muscle contractility and to determine the mechanism involved. Intact or denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Vitexin more significantly relaxed phorbol ester-induced vascular contraction than thromboxane A(2) or fluoride-induced contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, vitexin significantly inhibited phorbol ester-induced increases in pERK1/2 levels. On the other hand, it did not significantly inhibit thromboxane A(2)-induced increases in pMYPT1 levels suggesting the mechanism involving the primarily inhibition of MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of vitexin on agonist-induced vascular contraction regardless of endothelial function. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH | - |
dc.relation.isPartOf | PHARMAZIE | - |
dc.subject | SMOOTH-MUSCLE CONTRACTION | - |
dc.subject | INTEGRIN-LINKED KINASE | - |
dc.subject | RHO-KINASE | - |
dc.subject | MYOSIN PHOSPHATASE | - |
dc.subject | CA2+ ENTRY | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | SENSITIZATION | - |
dc.subject | HYPERTENSION | - |
dc.subject | ACTIVATION | - |
dc.subject | CALDESMON | - |
dc.title | The inhibitory effect of vitexin on the agonist-induced regulation of vascular contractility | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000334261300012 | - |
dc.identifier.doi | 10.1691/ph.2014.3803 | - |
dc.identifier.bibliographicCitation | PHARMAZIE, v.69, no.3, pp.224 - 228 | - |
dc.identifier.scopusid | 2-s2.0-84897135955 | - |
dc.citation.endPage | 228 | - |
dc.citation.startPage | 224 | - |
dc.citation.title | PHARMAZIE | - |
dc.citation.volume | 69 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Seo, Seung-Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE CONTRACTION | - |
dc.subject.keywordPlus | INTEGRIN-LINKED KINASE | - |
dc.subject.keywordPlus | RHO-KINASE | - |
dc.subject.keywordPlus | MYOSIN PHOSPHATASE | - |
dc.subject.keywordPlus | CA2+ ENTRY | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | SENSITIZATION | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CALDESMON | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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