Local Duplication of Gonadotropin-Releasing Hormone (GnRH) Receptor before Two Rounds of Whole Genome Duplication and Origin of the Mammalian GnRH Receptor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sefideh, Fatemeh Ameri | - |
dc.contributor.author | Moon, Mi Jin | - |
dc.contributor.author | Yun, Seongsik | - |
dc.contributor.author | Hong, Sung In | - |
dc.contributor.author | Hwang, Jong-Ik | - |
dc.contributor.author | Seong, Jae Young | - |
dc.date.available | 2020-02-28T18:41:33Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-02-03 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12830 | - |
dc.description.abstract | Gonadotropin-releasing hormone (GnRH) and the GnRH receptor (GnRHR) play an important role in vertebrate reproduction. Although many GnRHR genes have been identified in a large variety of vertebrate species, the evolutionary history of GnRHR in vertebrates is unclear. To trace the evolutionary origin of GnRHR we examined the conserved synteny of chromosomes harboring GnRHR genes and matched the genes to linkage groups of reconstructed vertebrate ancestor chromosomes. Consistent with the phylogenetic tree, three pairs of GnRHR subtypes were identified in three paralogous linkage groups, indicating that an ancestral pair emerged through local duplication before two rounds of whole genome duplication (2R). The 2R then led to the generation of six subtypes of GnRHR. Some subtypes were lost during vertebrate evolution after the divergence of teleosts and tetrapods. One subtype includes mammalian GnRHR and a coelacanth GnRHR that showed the greatest response to GnRH1 among the three types of GnRH. This study provides new insight into the evolutionary relationship of vertebrate GnRHRs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.subject | NEUROPEPTIDE-Y RECEPTOR | - |
dc.subject | DIFFERENTIAL LIGAND SELECTIVITY | - |
dc.subject | PROTEIN-COUPLED RECEPTORS | - |
dc.subject | MOLECULAR-CLONING | - |
dc.subject | CHROMOSOME DUPLICATIONS | - |
dc.subject | EXTRACELLULAR LOOP-3 | - |
dc.subject | CRITICAL DETERMINANT | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | CIONA-INTESTINALIS | - |
dc.subject | GENE REGIONS | - |
dc.title | Local Duplication of Gonadotropin-Releasing Hormone (GnRH) Receptor before Two Rounds of Whole Genome Duplication and Origin of the Mammalian GnRH Receptor | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000330626900142 | - |
dc.identifier.doi | 10.1371/journal.pone.0087901 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.9, no.2 | - |
dc.identifier.scopusid | 2-s2.0-84896886653 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Hong, Sung In | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NEUROPEPTIDE-Y RECEPTOR | - |
dc.subject.keywordPlus | DIFFERENTIAL LIGAND SELECTIVITY | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORS | - |
dc.subject.keywordPlus | MOLECULAR-CLONING | - |
dc.subject.keywordPlus | CHROMOSOME DUPLICATIONS | - |
dc.subject.keywordPlus | EXTRACELLULAR LOOP-3 | - |
dc.subject.keywordPlus | CRITICAL DETERMINANT | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | CIONA-INTESTINALIS | - |
dc.subject.keywordPlus | GENE REGIONS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.