Current status of pulmonary arterial hypertension in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Albert Youngwoo | - |
dc.contributor.author | Chung, Wook-Jin | - |
dc.date.available | 2020-02-27T02:41:49Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1284 | - |
dc.description.abstract | Pulmonary arterial hypertension (PAH) is characterized by remodeling of the distal pulmonary arteries resulting in high pulmonary vascular resistance and, eventually, right ventricular heart failure. Although current advances in PAH therapy have improved outcomes, poor survival remains a reality worldwide, including Korea. One of the most important issues in PAH is the late diagnosis, since screening or diagnostic efforts are often overlooked due to the rarity of disease. Data from Korean registries and observational cohorts show that delayed detection leads to increased morbidity. Additionally, low percentages of Korean patients are committed to intensive PAH-targeted therapy. Current Korean health insurance policies' lack of coverage for new PAH-targeted drugs and upfront combination therapy may also hamper the improvement of treatment outcomes. Understanding individual variability in response to therapeutics through deep phenotyping is a novel strategy that should be considered when treating PAH. Overall, early detection of PAH by proactive screening together with early, intensive, individualized PAH therapy using deep phenotyping is crucial for improving prognoses for PAH patients in Korea. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.subject | COMBINATION THERAPY | - |
dc.subject | CLINICAL-OUTCOMES | - |
dc.subject | JAPANESE PATIENTS | - |
dc.subject | CHINESE PATIENTS | - |
dc.subject | SURVIVAL | - |
dc.subject | MUTATIONS | - |
dc.subject | RECEPTOR | - |
dc.subject | BMPR2 | - |
dc.subject | MANAGEMENT | - |
dc.subject | DIAGNOSIS | - |
dc.title | Current status of pulmonary arterial hypertension in Korea | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000475850300002 | - |
dc.identifier.doi | 10.3904/kjim.2019.185 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.34, no.4, pp.696 - 707 | - |
dc.identifier.kciid | ART002475762 | - |
dc.identifier.scopusid | 2-s2.0-85069267317 | - |
dc.citation.endPage | 707 | - |
dc.citation.startPage | 696 | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 34 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Jang, Albert Youngwoo | - |
dc.contributor.affiliatedAuthor | Chung, Wook-Jin | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Pulmonary arterial hypertension | - |
dc.subject.keywordAuthor | Early diagnosis | - |
dc.subject.keywordAuthor | Pharmacotherapy | - |
dc.subject.keywordAuthor | Phenotyping | - |
dc.subject.keywordAuthor | Precision medicine | - |
dc.subject.keywordPlus | COMBINATION THERAPY | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | JAPANESE PATIENTS | - |
dc.subject.keywordPlus | CHINESE PATIENTS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | BMPR2 | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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