Soyo-san reduces depressive-like behavior and proinflammatory cytokines in ovariectomized female rats
DC Field | Value | Language |
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dc.contributor.author | Park, Hyun-Jung | - |
dc.contributor.author | Shim, Hyun-Soo | - |
dc.contributor.author | Chung, Sun Yong | - |
dc.contributor.author | Lee, Tae Hee | - |
dc.contributor.author | Shim, Insop | - |
dc.date.available | 2020-02-28T18:42:55Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-01-21 | - |
dc.identifier.issn | 1472-6882 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12894 | - |
dc.description.abstract | Background: Soyo-san is a traditional oriental medicinal formula, a mixture of 9 crude drugs, and it has been clinically used for treating mild depressive disorders. The role of pro- and anti-inflammatory cytokines in psychiatric disorders has been the focus of great research attention in recent years. In the present study, we detected the antidepressant effect of soyo-san in the ovariectomized and repeated stressed female rats. Methods: This study was designed to evaluate the antidepressant-like effect of soyo-san on the forced swimming test (FST). The rats were randomly divided into the following groups: the nonoperated and nonstressed group (non-op), the nonoperated and stressed group (non-op + ST), the ovariectomized and stress group (OVX) and sham operated and stressed group (sham), the ovariectomized and stressed group (OVX + ST), the ovariectomized, stressed and soyo-san 100 mg/kg treated group (SOY100) and the ovariectomized, stressed and soyo-san 400 mg/kg treated group (SOY400). The rats were exposed to immobilization stress (IMO) for 14day (2 h/14day), and soyo-san (100 mg/kg and 400 mg/kg) was administrated during the same time. In the same animals, the levels of corticosterone and interleukin-1-beta (IL-1 beta) were examined in the serum. Also, the change of IL-1 beta expression in brain regions was examined after behavior test. Results: In the FST, the lower dose (100 mg/kg) of extract was effective in reducing immobility, along with an increase in swimming time. The serum levels of corticosterone and IL-1 beta in the SOY groups were significantly lower than those in the control group. In the brain, the expression of IL-1 beta positive neurons in the control group were significantly increased in the paraventricular nucleus (PVN) and hippocampus compared to the non-op. However, soyo-san groups significantly reduced the IL-1 beta-ir neurons in the PVN and hippocampal regions compared to the control. Conclusion: The present results demonstrated that soyo-san effectively reduced behavioral and patho-physiological depression-like responses. Trial registration: Our results suggest that soyo-san may be useful for immune regulator in repeated stress-induced ovariectomized female rats. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.subject | PRO-INFLAMMATORY CYTOKINES | - |
dc.subject | STRESS-INDUCED CHANGES | - |
dc.subject | XIAO-YAO-SAN | - |
dc.subject | MODEL | - |
dc.subject | BRAIN | - |
dc.subject | MICE | - |
dc.subject | INTERLEUKIN-1-BETA | - |
dc.subject | NEUROINFLAMMATION | - |
dc.subject | CORTICOSTERONE | - |
dc.subject | CONSEQUENCES | - |
dc.title | Soyo-san reduces depressive-like behavior and proinflammatory cytokines in ovariectomized female rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000331123100001 | - |
dc.identifier.doi | 10.1186/1472-6882-14-34 | - |
dc.identifier.bibliographicCitation | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.14 | - |
dc.identifier.scopusid | 2-s2.0-84895062064 | - |
dc.citation.title | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Lee, Tae Hee | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PRO-INFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | STRESS-INDUCED CHANGES | - |
dc.subject.keywordPlus | XIAO-YAO-SAN | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | INTERLEUKIN-1-BETA | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.subject.keywordPlus | CORTICOSTERONE | - |
dc.subject.keywordPlus | CONSEQUENCES | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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