Time-dependent prognostic effect of high sensitivity C-reactive protein with statin therapy in acute myocardial infarction
DC Field | Value | Language |
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dc.contributor.author | Kang, Dong Oh | - |
dc.contributor.author | Park, Yoonjee | - |
dc.contributor.author | Seo, Ji Hoon | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Chae, Shung Chull | - |
dc.contributor.author | Ahn, Tae Hoon | - |
dc.contributor.author | Jang, Won Young | - |
dc.contributor.author | Kim, Woohyeun | - |
dc.contributor.author | Park, Eun Jin | - |
dc.contributor.author | Choi, Byoung Geol | - |
dc.contributor.author | Na, Jin Oh | - |
dc.contributor.author | Choi, Cheol Ung | - |
dc.contributor.author | Kim, Eung Ju | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Park, Chang Gyu | - |
dc.contributor.author | Seo, Hong Seog | - |
dc.date.available | 2020-02-27T02:41:51Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 0914-5087 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1289 | - |
dc.description.abstract | Background: Elevated high sensitivity C-reactive protein (hs-CRP) in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI) has prognostic value for future cardiovascular events. This study aimed to ascertain a valid prognostic time-period for predicting cardiovascular outcome based on baseline hs-CRP in AMI patients undergoing successful PCI on statin therapy. Methods: Overall, 4410 AMI patients were enrolled from the Korea Acute Myocardial Infarction-National Institutes of Health (KAMIR-NIH) registry. Participants were divided into groups according to cut-off values of baseline hs-CRP (1.0, 3.0, and 10.0 mg/L) and statin therapy intensity. The primary outcome was 36-month major adverse cardiovascular events (MACE), a composite of all-cause mortality, any myocardial infarction, and repeat revascularization. The secondary outcome was MACE developed 0-6, 6-12, and 12-36 months after AMI. Results: The overall incidence of 36-month MACE was significantly higher as baseline hs-CRP increased (by groups: 8.8% vs. 8.6% vs. 10.7% vs. 15.4%, log-rank p < 0.001). The prognostic effect of baseline hs-CRP was mostly confined to the first 6 months after AMI (0-6 months MACE by groups: 1.6% vs. 2.3% vs. 4.3% vs. 6.1%, log-rank p < 0.001) and attenuated in high-intensity statin users. Six months after AMI, this prognostic effect of baseline hs-CRP was remarkably reduced (6-12 month MACE by groups: 2.4% vs. 2.1% vs. 2.8% vs. 4.0%, log-rank p = 0.111,12-36 month MACE by groups: 4.7% vs. 4.1% vs. 4.0% vs. 6.2%, log-rank p = 0.218); however, high-intensity statin treatment showed a consistent improvement in outcome. The observed time-dependent prognostic effects remained consistent following multivariate analysis. Conclusions: The prognostic impact of elevated hs-CRP at baseline was most evident during the first 6 months after AMI; however, the use of high-intensity statin persistently improved the clinical outcome even after the resolution of inflammatory reactions. (C) 2019 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | JOURNAL OF CARDIOLOGY | - |
dc.subject | ACUTE CORONARY SYNDROMES | - |
dc.subject | FOLLOW-UP | - |
dc.subject | INFLAMMATION | - |
dc.subject | MORTALITY | - |
dc.subject | ATORVASTATIN | - |
dc.subject | DISEASE | - |
dc.subject | METAANALYSIS | - |
dc.subject | OUTCOMES | - |
dc.subject | MARKERS | - |
dc.subject | PARTICIPANTS | - |
dc.title | Time-dependent prognostic effect of high sensitivity C-reactive protein with statin therapy in acute myocardial infarction | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000476684000011 | - |
dc.identifier.doi | 10.1016/j.jjcc.2018.12.022 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CARDIOLOGY, v.74, no.1, pp.74 - 83 | - |
dc.identifier.scopusid | 2-s2.0-85061141143 | - |
dc.citation.endPage | 83 | - |
dc.citation.startPage | 74 | - |
dc.citation.title | JOURNAL OF CARDIOLOGY | - |
dc.citation.volume | 74 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Ahn, Tae Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | C-reactive protein | - |
dc.subject.keywordAuthor | Statins | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.subject.keywordAuthor | Percutaneous coronary intervention | - |
dc.subject.keywordAuthor | Coronary artery disease | - |
dc.subject.keywordPlus | ACUTE CORONARY SYNDROMES | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | ATORVASTATIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | PARTICIPANTS | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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