The Smad7-Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-beta
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae-Aug | - |
dc.contributor.author | Kang, Jin Muk | - |
dc.contributor.author | Hyun, Ja-Shil | - |
dc.contributor.author | Lee, Bona | - |
dc.contributor.author | Kim, Staci Jakyong | - |
dc.contributor.author | Yang, Eun-Sung | - |
dc.contributor.author | Hong, Suntaek | - |
dc.contributor.author | Lee, Ho-Jae | - |
dc.contributor.author | Fujii, Makiko | - |
dc.contributor.author | Niederhuber, John E. | - |
dc.contributor.author | Kim, Seong-Jin | - |
dc.date.available | 2020-02-28T18:43:11Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-01-15 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12904 | - |
dc.description.abstract | In most human cancers the Myc proto-oncogene is highly activated. Dysregulation of Myc oncoprotein contributes to tumorigenesis in numerous tissues and organs. Thus, targeting Myc stability could be a crucial step for cancer therapy. Here we report Smad7 as a key molecule regulating Myc stability and activity by recruiting the F-box protein, Skp2. Ectopic expression of Smad7 downregulated the protein level of Myc without affecting the transcription level, and significantly repressed its transcriptional activity, leading to inhibition of cell proliferation and tumorigenic activity. Furthermore, Smad7 enhanced ubiquitylation of Myc through direct interaction with Myc and recruitment of Skp2. Ablation of Smad7 resulted in less sensitivity to the growth inhibitory effect of TGF-beta by inducing stable Myc expression. In conclusion, these findings that Smad7 functions in Myc oncoprotein degradation and enhances the cytostatic effect of TGF-beta signaling provide a possible new therapeutic approach for cancer treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | COMPANY OF BIOLOGISTS LTD | - |
dc.relation.isPartOf | JOURNAL OF CELL SCIENCE | - |
dc.subject | GROWTH-FACTOR-BETA | - |
dc.subject | BOX PROTEIN SKP2 | - |
dc.subject | C-MYC | - |
dc.subject | UBIQUITIN LIGASE | - |
dc.subject | TRANSCRIPTIONAL ACTIVATION | - |
dc.subject | CELL-PROLIFERATION | - |
dc.subject | DEGRADATION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | RECEPTOR | - |
dc.subject | ID2 | - |
dc.title | The Smad7-Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-beta | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000329789200016 | - |
dc.identifier.doi | 10.1242/jcs.136028 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL SCIENCE, v.127, no.2, pp.411 - 421 | - |
dc.identifier.scopusid | 2-s2.0-84892502131 | - |
dc.citation.endPage | 421 | - |
dc.citation.startPage | 411 | - |
dc.citation.title | JOURNAL OF CELL SCIENCE | - |
dc.citation.volume | 127 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Hong, Suntaek | - |
dc.contributor.affiliatedAuthor | Lee, Ho-Jae | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Myc | - |
dc.subject.keywordAuthor | Smad7 | - |
dc.subject.keywordAuthor | Skp2 | - |
dc.subject.keywordAuthor | Protein stability | - |
dc.subject.keywordAuthor | Ubiquitylation | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | BOX PROTEIN SKP2 | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVATION | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ID2 | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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