Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Young-Sun | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.available | 2020-02-28T18:44:11Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12952 | - |
dc.description.abstract | Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released from intestinal L-cells in response to nutrients. GLP-1 lowers blood glucose levels by stimulating insulin secretion from pancreatic beta-cells in a glucose-dependent manner. In addition, GLP-1 slows gastric emptying, suppresses appetite, reduces plasma glucagon, and stimulates glucose disposal, which are beneficial for glucose homeostasis. Therefore, incretin-based therapies such as GLP-1 receptor agonists and inhibitors of dipeptidyl peptidase IV, an enzyme which inactivates GLP-1, have been developed for treatment of diabetes. This review outlines our knowledge of the actions of GLP-1 on insulin secretion and biosynthesis, beta-cell proliferation and regeneration, and protection against beta-cell damage, as well as the involvement of recently discovered signaling pathways of GLP-1 action, mainly focusing on pancreatic beta-cells. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.relation.isPartOf | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.subject | STIMULATED INSULIN-SECRETION | - |
dc.subject | IMPROVED GLUCOSE-HOMEOSTASIS | - |
dc.subject | GENE PROMOTER ACTIVITY | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | ALPHA-CELLS | - |
dc.subject | GLP-1 RECEPTOR | - |
dc.subject | DIABETIC-RATS | - |
dc.subject | NOD MICE | - |
dc.subject | TRANSCRIPTION FACTORS | - |
dc.subject | COMBINATION THERAPY | - |
dc.title | Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000328799400003 | - |
dc.identifier.doi | 10.1016/j.metabol.2013.09.010 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, v.63, no.1, pp.9 - 19 | - |
dc.identifier.scopusid | 2-s2.0-84890118673 | - |
dc.citation.endPage | 19 | - |
dc.citation.startPage | 9 | - |
dc.citation.title | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.citation.volume | 63 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Young-Sun | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Pancreatic islet | - |
dc.subject.keywordAuthor | Incretin hormone | - |
dc.subject.keywordAuthor | Type 2 diabetes | - |
dc.subject.keywordAuthor | Proliferation | - |
dc.subject.keywordAuthor | Anti-apoptosis | - |
dc.subject.keywordPlus | STIMULATED INSULIN-SECRETION | - |
dc.subject.keywordPlus | IMPROVED GLUCOSE-HOMEOSTASIS | - |
dc.subject.keywordPlus | GENE PROMOTER ACTIVITY | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | ALPHA-CELLS | - |
dc.subject.keywordPlus | GLP-1 RECEPTOR | - |
dc.subject.keywordPlus | DIABETIC-RATS | - |
dc.subject.keywordPlus | NOD MICE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | COMBINATION THERAPY | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.