Success Rate and Risk Factors for Failure of Empirical Antifungal Therapy with Itraconazole in Patients with Hematological Malignancies: A Multicenter, Prospective, Open-Label, Observational Study in Korea
DC Field | Value | Language |
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dc.contributor.author | Kim, Soo-Jeong | - |
dc.contributor.author | Cheong, June-Won | - |
dc.contributor.author | Min, Yoo Hong | - |
dc.contributor.author | Choi, Young Jin | - |
dc.contributor.author | Lee, Dong-Gun | - |
dc.contributor.author | Lee, Je-Hwan | - |
dc.contributor.author | Yang, Deok-Hwan | - |
dc.contributor.author | Lee, Sang Min | - |
dc.contributor.author | Kim, Sung-Hyun | - |
dc.contributor.author | Kim, Yang Soo | - |
dc.contributor.author | Kwak, Jae-Yong | - |
dc.contributor.author | Park, Jinny | - |
dc.contributor.author | Kim, Jin Young | - |
dc.contributor.author | Kim, Hoon-Gu | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Ryoo, Hun-Mo | - |
dc.contributor.author | Jang, Jun Ho | - |
dc.contributor.author | Kim, Min Kyoung | - |
dc.contributor.author | Kang, Hye Jin | - |
dc.contributor.author | Cho, In Sung | - |
dc.contributor.author | Mun, Yeung Chul | - |
dc.contributor.author | Jo, Deog-Yeon | - |
dc.contributor.author | Kim, Ho Young | - |
dc.contributor.author | Park, Byeong-Bae | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.date.available | 2020-02-28T18:44:16Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12958 | - |
dc.description.abstract | We assessed the success rate of empirical antifungal therapy with itraconazole and evaluated risk factors for predicting the failure of empirical antifungal therapy. A multicenter, prospective, observational study was performed in patients with hematological malignancies who had neutropenic fever and received empirical antifungal therapy with itraconazole at 22 centers. A total of 391 patients who had abnormal findings on chest imaging tests (31.0%) or a positive result of enzyme immunoassay for serum galactomannan (17.6%) showed a 56.5% overall success rate. Positive galactomannan tests before the initiation of the empirical antifungal therapy (P = 0.026, hazard ratio [ HR], 2.28; 95% confidence interval [CI], 1.10-4.69) and abnormal findings on the chest imaging tests before initiation of the empirical antifungal therapy (P = 0.022, HR, 2.03; 95% CI, 1.11-3.71) were significantly associated with poor outcomes for the empirical antifungal therapy. Eight patients (2.0%) had premature discontinuation of itraconazole therapy due to toxicity. It is suggested that positive galactomannan tests and abnormal findings on the chest imaging tests at the time of initiation of the empirical antifungal therapy are risk factors for predicting the failure of the empirical antifungal therapy with itraconazole. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.subject | LIPOSOMAL AMPHOTERICIN-B | - |
dc.subject | INFECTIOUS-DISEASES SOCIETY | - |
dc.subject | STEM-CELL TRANSPLANTATION | - |
dc.subject | NEUTROPENIC PATIENTS | - |
dc.subject | INVASIVE ASPERGILLOSIS | - |
dc.subject | PERSISTENT FEVER | - |
dc.subject | FUNGAL-INFECTIONS | - |
dc.subject | CANCER | - |
dc.subject | GALACTOMANNAN | - |
dc.subject | GUIDELINES | - |
dc.title | Success Rate and Risk Factors for Failure of Empirical Antifungal Therapy with Itraconazole in Patients with Hematological Malignancies: A Multicenter, Prospective, Open-Label, Observational Study in Korea | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000330508600010 | - |
dc.identifier.doi | 10.3346/jkms.2014.29.1.61 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.1, pp.61 - 68 | - |
dc.identifier.kciid | ART001844595 | - |
dc.identifier.scopusid | 2-s2.0-84907424229 | - |
dc.citation.endPage | 68 | - |
dc.citation.startPage | 61 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Park, Jinny | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Hematological Malignancy | - |
dc.subject.keywordAuthor | Itraconazole | - |
dc.subject.keywordAuthor | Empirical Antifungal Therapy | - |
dc.subject.keywordAuthor | Galactomannan Test | - |
dc.subject.keywordPlus | LIPOSOMAL AMPHOTERICIN-B | - |
dc.subject.keywordPlus | INFECTIOUS-DISEASES SOCIETY | - |
dc.subject.keywordPlus | STEM-CELL TRANSPLANTATION | - |
dc.subject.keywordPlus | NEUTROPENIC PATIENTS | - |
dc.subject.keywordPlus | INVASIVE ASPERGILLOSIS | - |
dc.subject.keywordPlus | PERSISTENT FEVER | - |
dc.subject.keywordPlus | FUNGAL-INFECTIONS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | GALACTOMANNAN | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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