Inhibitory effects of water-soluble extracts of barley, malt, and germinated barley on melanogenesis in melan-a cells
- Authors
- Lee, H.M.; Lee, S.O.; Moon, E.; Do, M.H.; Kim, S.Y.
- Issue Date
- Mar-2014
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Barley; Germination; Malt; Melanogenesis; Tyrosinase; Tyrosinase-related protein 2
- Citation
- Natural Product Sciences, v.20, no.1, pp.33 - 38
- Journal Title
- Natural Product Sciences
- Volume
- 20
- Number
- 1
- Start Page
- 33
- End Page
- 38
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13025
- ISSN
- 1226-3907
- Abstract
- In recent times, the demand for edible medication for the treatment of hyperpigmentation has increased significantly. Therefore, the discovery of a stable, safe and inexpansive antimelanogenic component from natural substances, such as grains, is of particular interest. The levels and activities of some metabolites and/ or enzymes can be increased. In the present study, we investigated the antimelanogenic effects of water-soluble extracts from barley (BE), malt (ME) and germinated barley (GBE) in melan-a cells. The inhibitory effects of ME and GBE on melanin production were significantly greater than that of BE. Interestingly, the content of ferulic acid, the proposed active component of barley, was also higher in ME and GBE than in BE by HPLC analysis. Western blot analysis of the expression of melanogenic enzymes in melan-a cells treated with BE, ME or GBE indicated the expression of both tyrosinase and tyrosinase-related protein 2 (TRP-2) significantly decreased after treatment with BE, ME or GBE. These results suggest that besides BE, ME and GBE also inhibit melanin production most likely through suppression of tyrosinase and TRP-2 expression. ME and GBE were more efficacious at inhibiting melanin production than BE was and may also represent potential skin-whitening agents.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.