A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity
DC Field | Value | Language |
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dc.contributor.author | Shin, Myoung-Sook | - |
dc.contributor.author | Yu, Jun Sang | - |
dc.contributor.author | Lee, Jaemin | - |
dc.contributor.author | Ji, Young Seok | - |
dc.contributor.author | Joung, Hee Joung | - |
dc.contributor.author | Han, Yu-Mee | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.available | 2020-02-27T02:41:58Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1303 | - |
dc.description.abstract | Curcumin is a polyphenol compound derived from the rhizomes of Curcuma longa that exhibits antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. However, its low solubility in aqueous solutions, low absorption following oral administration, and rapid degradation limit its use as a functional food material. In this study, a hydroxypropyl methylcellulose-based solid dispersion of curcumin (DW-CUR 20) was prepared and its bioavailability was evaluated. In addition, its therapeutic efficacy as a hepatoprotective agent was investigated using the model of tert-butyl hydroperoxide (t-BHP)-induced hepatocyte damage. The rat plasma pharmacokinetic study showed that the oral curcumin bioavailability of DW-CUR 20 significantly increased compared to that of non-formulated curcumin. DW-CUR 20 showed a concentration-dependent hepatocyte protective effect on t-BHP-induced HepG2 cells. DW-CUR 20 inhibited the release of lactate dehydrogenase and decreased apoptosis-related proteins such as Poly (ADP-ribose) polymerase, cleaved caspase-7 and cleaved caspase-8 on t-BHP-treated HepG2 cells. These findings suggest that DW-CUR 20 could be a promising formulation for enhancing the therapeutic efficiency of curcumin and for improving the safety. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | BIOMOLECULES | - |
dc.subject | CULTURED-HEPATOCYTES | - |
dc.subject | ORAL BIOAVAILABILITY | - |
dc.subject | LIPID NANOPARTICLES | - |
dc.subject | LIVER-DAMAGE | - |
dc.subject | IN-VITRO | - |
dc.subject | STABILITY | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | PATHWAY | - |
dc.subject | DEATH | - |
dc.subject | DRUG | - |
dc.title | A Hydroxypropyl Methylcellulose-Based Solid Dispersion of Curcumin with Enhanced Bioavailability and Its Hepatoprotective Activity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000478767500009 | - |
dc.identifier.doi | 10.3390/biom9070281 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES, v.9, no.7 | - |
dc.identifier.scopusid | 2-s2.0-85069987052 | - |
dc.citation.title | BIOMOLECULES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Shin, Myoung-Sook | - |
dc.contributor.affiliatedAuthor | Lee, Jaemin | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | hydroxypropyl methylcellulose | - |
dc.subject.keywordAuthor | curcumin | - |
dc.subject.keywordAuthor | bioavailability | - |
dc.subject.keywordAuthor | hepatoprotective | - |
dc.subject.keywordPlus | CULTURED-HEPATOCYTES | - |
dc.subject.keywordPlus | ORAL BIOAVAILABILITY | - |
dc.subject.keywordPlus | LIPID NANOPARTICLES | - |
dc.subject.keywordPlus | LIVER-DAMAGE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | DRUG | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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