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Screening of Vietnamese herbal medicines with inhibitory effect on aldose reductase (XI)베트남 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(XI)
- Other Titles
- 베트남 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(XI)
- Authors
- Choi, S.-J.; Kim, Y.S.; Kim, J.H.; Kim, J.S.
- Issue Date
- Dec-2014
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Aldose reductase inhibitor; Diabetic complications; Vietnamese herbal medicines
- Citation
- Korean Journal of Pharmacognosy, v.45, no.4, pp.366 - 375
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 45
- Number
- 4
- Start Page
- 366
- End Page
- 375
- ISSN
- 0253-3073
- Abstract
- Aldose reductase (AR) has been indicated the critical enzyme of the polyol pathway in the development of the diabetic complications. In this study, 119 Vietnamese herbal medicines have been investigated for inhibitory activities on AR. Among them, 7 herbal medicines, Synedrella nodiflora (stems and leaves), Combretum sundaicum (stems and leaves), Argyreia acuta (stems and leaves), Platea latifolia (whole plants), Linociera sangda (whole plants), Rhaphiolepis indica (whole plants), Harrisonia perforata (stems and leaves) and 2 fractions from Harrisonia perforata (stems and leaves) with EtOAc and BuOH, exhibited a significant inhibitory activity against AR. Particularly, S. nodiflora, A. acuta and H. perforata (stems and leaves) showed 1.0-1.8 times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG). © 2015, Korean Society of Pharmacognosy. All rights reserved.
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Related Researcher
- Kim, Joo-Hwan
- BioNano Technology (Department of Life Sciences)