Clinical features of non-alcoholic fatty liver disease in cryptogenic hepatocellular carcinoma원인 미상 간세포암이 갖는 비알코올 지방간의 임상적 특징
- Other Titles
- 원인 미상 간세포암이 갖는 비알코올 지방간의 임상적 특징
- Authors
- Rim, M.Y.; Kwon, O.S.; Ha, M.; Kim, J.S.; Ko, K.I.; Kim, D.K.; Jang, P.K.; Han, J.Y.; Park, P.H.; Jung, Y.K.; Choi, D.J.; Kim, Y.S.; Kim, J.H.
- Issue Date
- May-2014
- Publisher
- 대한소화기학회
- Keywords
- Cryptogenic; Hepatocellular carcinoma; Metabolic syndrome; Nonalcoholic fatty liver disease; 원인 미상; 간세포암; 대사 증후군; 비알코올 지방간 질환
- Citation
- The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.63, no.5, pp.292 - 298
- Journal Title
- The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
- Volume
- 63
- Number
- 5
- Start Page
- 292
- End Page
- 298
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13140
- DOI
- 10.4166/kjg.2014.63.5.292
- ISSN
- 1598-9992
- Abstract
- BACKGROUND/AIMS: Nonalcoholic fatty liver disease (NAFLD) may be one of the important causes of cryptogenic hepatocellular carcinoma (HCC). The aim of this study was to evaluate whether patients with cryptogenic HCC share clinical features similar to that of NAFLD.METHODS: Cryptogenic HCC was defined as HCC that occurs in patients with the following conditions: HBsAg(-), anti-HCV(-), and alcohol ingestion of less than 20 g/day. All patients diagnosed with cryptogenic HCC from 2005 to 2012 (cryptogenic HCC group), and all patients diagnosed with HBV associated HCC between 2008 and 2012 (HBV-HCC group) were enrolled in the present study. Clinical features, BMI, lipid profiles, presence of diabetes mellitus, hypertension, and metabolic syndrome were compared between the two groups.RESULTS: Cryptogenic HCC group was composed of 35 patients (19 males and 16 females) with a mean age of 70 ± 11 years. HBV-HCC group was composed of 406 patients (318 males and 88 females) with a mean age of 56 ± 7 years. Patients in the cryptogenic HCC group were older (p=0.001) and female dominant (p=0.042) than those in the HBV-HCC group. There were no differences in the laboratory test results including lipid profiles and Child-Turcotte-Pugh class between the two groups. Patients in the cryptogenic HCC group had higher prevalence of diabetes (37% vs. 17%, p=0.015), hypertension (49% vs.27%, p=0.051), metabolic syndrome (37% vs. 16%, p=0.001), and higher BMI (25.3 kg/m(2) vs. 24.1 kg/m(2), p=0.042) than those in the HBV- HCC group. The tumor stage was more advanced (stage III and IV) at diagnosis in the cryptogenic HCC group than in the HBV-HCC group (60% vs. 37%, p=0.007).CONCLUSIONS: Cryptogenic HCC has clinical features similar to that of NAFLD and is diagnosed at a more advanced tumor stage.
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