갈근이 비만 랫드 간조직의 비만관련 유전자 발현에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 신윤상 | - |
dc.contributor.author | 황귀서 | - |
dc.date.available | 2020-02-28T19:43:53Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1226-7066 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13296 | - |
dc.description.abstract | Objective : It is known that Pueriaria lobata has an anti-osteoporetic effect, anti-cancer effect, anti-pyretic effect, and anti-diabetic effect. The aim of this study was to evaluate anti-obesity effect of Pueriaria lobata extract (PLE), and elucidate the effect of it on gene expression related to lipid metabolism. Method : The experiments were performed with the use of ovariectomized rats as estrogen-deficient obesity model. They were grouped NC (normal control), OC (estrogen-deficient control), PLH (100mg/kg of PLE), PLL (20mg/kg). PLE was orally administered for 6 weeks. Body weights and serum lipid level were estimated, and real-time PCR was performed to investigate the effect of PLE on gene expression in liver. Results : PLE decreased the body weight and serum cholesterol and triglyceride, but increased HDL-cholesterol. And PLE increased leptin, CYP27, CPT1, CYP8B1, ACAT2, LDLR, and SCD1, but reduced PPARγ, PGC1A, HMG-CoA-R, ACAT1, SCD1, and APoB gene expression in liver tissue of rat with estrogen-deficient obesity. Conclusion : It is concluded that Pueriaria lobata reduced body weight, and its effect was expressed by regulation of gene expression related to lipid metabolism in rats with estrogen-deficient obesity. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한예방한의학회 | - |
dc.relation.isPartOf | 대한예방한의학회지 | - |
dc.title | 갈근이 비만 랫드 간조직의 비만관련 유전자 발현에 미치는 영향 | - |
dc.title.alternative | The effects of Pueraria lobata extract on gene expression in liver tissue of rat with estrogen-deficient obesity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한예방한의학회지, v.18, no.3, pp.117 - 128 | - |
dc.identifier.kciid | ART001947591 | - |
dc.citation.endPage | 128 | - |
dc.citation.startPage | 117 | - |
dc.citation.title | 대한예방한의학회지 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 신윤상 | - |
dc.contributor.affiliatedAuthor | 황귀서 | - |
dc.subject.keywordAuthor | Pueriaria lobata | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | estrogen | - |
dc.subject.keywordAuthor | gene expression | - |
dc.description.journalRegisteredClass | kci | - |
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